Sebaceous hyperplasia: systemic treatment with isotretinoin

The study aimed to verify the therapeutic action of isotretinoin in the treatment of sebaceous hyperplasia. During two months, 20 patients with sebaceous hyperplasia took isotretinoin at a dosage of 1mg/kg per day. Their skin lesions were counted and photographed before and after treatment and re-evaluated two years later. The average number of sebaceous hyperplasia lesions before treatment was 24 per patient. At the end of two months of therapy, the number of lesions decreased to 2 per patient. The statistically analyzed data showed a reduction in the number of lesions following isotretinoin use (p < 0.05). Two years after the end of the treatment, the average number of sebaceous hyperplasia lesions was 4 per patient. There were no severe side effects. Thus, the data analysis suggests that isotretinoin is a safe and effective drug for treating the disease under study.

Carcinoma sebáceo / Sebaceous carcinoma

El carcinoma sebáceo es un tumor maligno agresivo poco frecuente, con diferenciación sebácea,que afecta a adultos de edad avanzada. Se lo clasifica en ocular y extraocular, y su clínica no es característica. Presentamos cinco pacientes con carcinoma sebáceo, tres de localización extraocular, uno de los cuales se diagnosticó en estadio in situ, y dos oculare...

Hiperplasia sebácea cutânea: estudo piloto para a correlação da doença com hormônios androgênios / Sebaceous hyperplasia: a pilot study to correlate this skin disease with circulating androgen levels

FUNDAMENTOS: As glândulas sebáceas são suscetíveis à ação dos hormônios androgênios e apresentam proliferação benigna com a idade, ou seja, hiperplasia. OBJETIVOS: Estudo piloto para verificar se há correlação entre a taxa de hormônios masculinos circulantes e o aumento da incidência da hiperplasia das glândulas sebáceas. MÉTODOS: 16 pacientes do sexo feminino, com diagnóstico de hiperplasia sebácea cutânea, foram comparados a um grupo-controle de mesmo gênero e idades semelhantes, sem a doença. Ambos os grupos foram submetidos a testes de dosagem sanguínea para avaliação das taxas de hormônios androgênios circulantes (testosterona livre e total, androstenediona). Os resultados foram tabulados e analisados estatisticamente. RESULTADOS: Os dados demonstraram não haver mudanças nos níveis de hormônios masculinos circulantes dos pacientes com hiperplasia sebácea cutânea, quando comparados ao grupo-controle. CONCLUSÃO: Os dados sugerem que não há alterações estatisticamente significantes nas taxas dos hormônios circulantes (testosterona livre e total, androstenediona, deidroepiandrosterona, sulfato de deidroepiandrosterona) dos pacientes com hiperplasia sebácea cutânea.

BACKGROUND: The sebaceous glands are susceptible to the effects of androgens. A benign proliferation of these hormones, i.e. hyperplasia, occurs with age. OBJECTIVES: This was a pilot study to demonstrate whether any correlation exists between circulating androgen levels and an increase in the incidence of sebaceous hyperplasia. METHODS: Sixteen female patients with a diagnosis of sebaceous hyperplasia were compared to a control group of females of a similar age without the disease. Blood tests were performed on participants of both groups to measure circulating androgen levels (free and total testosterone and androstenedione levels). Results were tabulated for statistical analysis. RESULTS: These data showed no statistically significant differences in circulating androgen levels between the patients with sebaceous hyperplasia and the control group. CONCLUSION: These data suggest that no significant changes occur in circulating androgen levels [free and total testosterone, androstenedione, dehydroepiandrosterone (DHEA) and DHEA sulfate] in patients with sebaceous hyperplasia.

Los gránulos de Fordyce: reporte de un caso / Fordyce grains: report of a case

Se expone el caso clínico de un paciente de 67 años de edad el cual presenta múltiples lesiones papulares, redondeadas, de color amarillento, ubicadas en la mucosa de ambos carrillos (a la altura de los molares superiores y en cercanía con el conducto excretor Stenon de la glándula parótida) y en el fondo de ambos vestíbulos de la mandíbula. A estas lesiones se les dio el diagnóstico definitivo de: Gránulos de Fordyce. De igual manera, en este estudio y basándose en la bibliografía, se señalan en detalle las características clínicas e histológicas más relevantes de estas lesiones, a objeto de orientar al odontólogo en el diagnostico de las mismas para evitar que las confunda con verdaderas patologías

The clinical case of a 67 year old patient is presented. He suffers from multiple papule injuries, rounded, of yellowish color, located in the mucous of both cheeks (at the height of the superior molars and close to the Stenon excretory way of the parotid gland) and at heart of both lobbies of the jaw. These injuries were diagnosed as Fordyce Grains. Likewise, in this study and based on the literature, the clinical and histological details of these injuries are described in detail, in order to guide dentists in their diagnosis and so they do not confuse them with real pathologies.

Survery of cutaneous complications after renal transplantation in Emam Reza [PH] and Qaem Hospitals, Mashhad

Renal transplantation is an appropriate treatment for end stage renal disease and helps prolongation of patients survival with better quality, but immunosuppressive drugs that are used for inhibition of rejection after transplantation may cause some adverse effects in other organs such as the skin. Apparently, early recognition of those side effects and their appropriate management can reduce morbidity and mortality. This study was designed to study cutaneous complications in renal transplantation recipients. In this descriptive study cutaneous side effects in one hundred kidney transplant patients who were admitted to transplantation clinics of Qaem and Emam Reza hospital of Mashhad during a six-month period [April to September 2003] were studied. Sixty-five patients were males and 35 cases were females. The mean age was 36 years [SD=14]. Totally, cutaneous manifestations were observed in 88% of patients. In a descending order they included hypertrichosis, cushinoid appearance, gingival hyperplasia, steroid acne, common warts, herpes simplex infection, superficial fungal infection, candidiasis, actinic keratosis, porokeratosis, lymphoma, stria, telangiectasia and sebaceous hyperplasia. Early recognition of these complications and appropriate treatment of them can reduce probable mortality and morbidity

Mucinosis folicular / Mucinosis folicular

Las mucinosis constituyen un grupo muy heterogéneo de dermatosis caracterizadas por el depósito anormal de mucina en la dermis (mucinosis dérmica) o en los folículos pilosos o aparato sebáceo (mucinosis folicular). Se presenta el caso de una mujer adulta con mucinosis folicular, acompañada de policondritis recidivante de pabellón auricular, remarcando la importancia del diagnóstico y la remisión espontánea en corto tiempo en ambos casos

Nevo sebáceo de Jadahsson / Sebaceous Nevo of Jadahsson

Analiza que el nevo sebáceo de Jadahsson (NSJ), es una lesión cutánea hamartomatosa formada por grandes glñandulas sebáceas que suele aparecer desde el nacimeinto. Presentamos un paciente de sexo femenino de 19 años de edad, con Nebo Sebáceo lineal de localización inusual, en el que se instauró tratamiento quirúrgico conexcelentes resultados. Realizamos una revisión completa...

Lesiones cutáneas en recién nacidos / Skin injuries in neonates

Las lesiones cutáneas en recién nacidos son frecuentes. La mayoría son banales y transitorias; sin embargo, algunas requieren seguimiento o son marcadores de otras enfermedades importantes. El objetivo de este trabajo fue determinar la frecuencia de presentación y algunas características de diferentes lesiones cutáneas en un grupo de 1.203 recién nacidos de hasta 72 horas de vida. De ellos, 91,2 por ciento presentó alguna lesión cutánea clasificada según criterios clínicos como pigmentada, vascular y otros. Los resultados mostraron mancha mongólica en 45 por ciento, nevos pigmentados en 2 por ciento y manchas café con leche en 2 por ciento. La lesión vascular más frecuente fue la mancha salmón (44 por ciento). Otras lesiones cutáneas frecuentes fueron eritema tóxico (42 por ciento) e hiperplasia de glándulas sebáceas (32 por ciento). El reconocimiento adecuado de lesiones cutáneas al momento del nacimiento es muy importante para definir pronóstico y evolución

Alopecia mucinosa: informe de un caso / A case of alopecia mucinosa

Alopecia mucinosa es una enfermedad inflamatoria caracterizada por el depósito de mucopolizacáridos ácidos en la unidad pilosebácea con alopecia reversible. Puede representar una forma idiopática benigna o un marcador cutáneo de malignidad subyacente, según los casos. Se presenta un caso clínico