effect of oxamniquine and praziquantel on gamma amino butyric acid and L-glutamic acid contents in the brains of schistosoma mansoni infected mice

The gamma amino butyric acid [GABA] and L-glutamic acid contents were determined in the whole brains of Schistosoma mansoni infected mice, after the eighth week of infection. The L-glutamic acid content was not affected by infection

Effect of oxamniquine and praziquantel on liver monoamine oxidase [MAO] in schistosoma mansoni infected mice

The hepatic MAO activity was determined in Schistosoma mansoni infected mice after the eighth week of infection. A marked drop in enzyme activity was noticed. Treatment of these infected mice using one of the recently introduced antischistosomal agents, either oxamniquine or praziquantel, resulted in improvement of MAO activity to the normal level. This may suggest that regression of the pathological changes, accompanying schistosomal hepatic fibrosis in mice, may result from early effective treatment

Effect of antischistosomal drug [oxamniquine] of the liver function in normal and schistosomal infected mice

Effect of oxamniquine [oral single dose of 50 mg/Kg. body weight [b.w] on the liver function in normal and schistosoma manson [S. mansoni] infected mice was, biochemicaly and histopathologicaly studied. The experiments tested for 2 months. Schistosomiasis caused abnormality in the liver after 3 months from the infection characterized by marked elevation in S. GPT, S. GOT and alkaline phosphatase [AP]. Oxamniquine had no side effect in the normal mice. Moreover it had desirable effect in the infected mice as evidenced by decreasing the highly significant elevations indicated in the test enzymes. Meanwhile, no pathological alteration was observed in the liver cells of either normal or infected mice after oxamniquine administration

Serum proteins and triglycerides after oxamniquine administration in normal and schistosomal infected mice

The effect of oxamniquine on serum proteins and triglycerides was studied in mice. A single oral dose of oxamniquine [50 mg/kg b.w.] was administered after three months from the schistosomal infection. The same dose was given also to normal control group of animals. Blood samples were withdrawn prior to drug administration and periodically every two weeks for two months. It was concluded that oxamniquine caused an elevation on serum alpha1, alpha2 beta and total globulins in normal mice. In schistosomal infected mice, oxamniquine administration inhibited the abnormalities in A/G ratio and significantly decreased triglycerides