Felodipina versus nifedipina en el tratamiento de la crisis hipertensiva / Felodipine vs nifedipine in treatment of hypertensive crisis

Comparar la eficacia de la felodipina un calcio antagonista en el tratamiento de la crisis hipertensiva con una terapia de referencia, la nifedipina. Cincuenta y cuatro pacientes con edades comprendidas entre 30 y 80 años de edad que consultaron a la sala de emergencia con cifras tensionales diastólicas mayores de 110 mmHg a los cuales se les administro por método ciego simple una tableta de felodipina masticada o el contenido de una cápsula de nifedipina sublingual. Tanto felodipina como nifedipina fueron efectivos para disminuir las cifras tensionales, no se observaron diferencias significativas entre los medicamentos para este parámetro. La felodipina es al menos tan efectiva como la nifedipina para el tratamiento de las crisis hipertensivas, ambos son bien tolerados

Higher AUCs on oral administration of omeprazole and felodipine in Indian volunteers--are they clinically important?

Bioavailability studies with single oral doses of omeprazole 20 mg (enteric coated formulation) and felodipine 10 mg (extended release formulation) were performed in Indian volunteers to confirm that adequate plasma concentrations are obtained in Indian subjects. Plasma samples were analysed by chromatographic methods. The AUCs of omeprazole were about 3 fold higher and those of felodipine 2 fold higher than AUCs reported in Western subjects. This has no toxicological implications with respect to omeprazole, but whether lower dose of omeprazole may be sufficient in Indian patients with acid related diseases would require acid inhibition studies. In the case of felodipine the higher AUCs in Indian subjects suggest a need for a lower strength formulation (2.5 mg) to fine-titrate the dosage to obtain optimal antihypertensive effects with minimal adverse effects.

Eficacia e tolerabilidade da felodipina em dose unica diaria e nifedipina, duas vezes ao dia, como monoterapia na hipertensao arterial leve / Effectiveness and tolerability of felodipine once daily and nifedipine twice daily as monotherapies for mild hypertension

Esse estudo foi projetado para comparar a felodipina de liberacao prolongada com a nifedipina retard em termos de seu efeito anti-hipertensivo,telerabilidade e impacto na qualidade de vida.Setenta e sete pacientes com hipertensao arterial primaria e pressao diastolica de 95-110 mmHg,na posicao supina,foram randomizados para quatro semanas de tratamento duplo-cego com felodipina,na dose de 5mg,uma vez por dia,ou nifedipina,na dose de 20mg,duas vezes por dia.A pressao arterial foi medida no termino do intervalo posologico,isto e,24 e 12 horas depois da administracao da felodipina e nifedipina,respectivamente.Foram registrados os efeitos adversos relatados espontaneamente ou em resposta a uma pergunta aberta e a qualidade de vida foi avaliada,usando-se dois questionarios auto-administrados.Depois de quatro semans de tratamento a pressao arterial media,na posicao supina,diminuiu de 165/104 mmHg para 154/91mmHg no grupo tratado com a felodipina e de 169/102mmHg para 155/90mmHg no grupo tratado com a nifedipina.Nao huve diferencas sisgnificativas na reducao da pressao arterial na posicao supina ou em pe entre os grupos.A qualidade de vida pareceu ser semelhante entreos tratamentos,mas foram relatadoa mais reacoes adversas,em particular,edema maleolar e rubor,com a nifedipinado que com a felodipina.As reacoes adversas exigiam a interrupcao do tratamanto em 5 de 40 pacientes do grupo da nifedipina,em comparacao com 1 de 37 pacientes do grupo da felodipina.Em conclusao,a felodipina na dose de 5mg,uma vez por dia,e anifedipina,na dose de 20mg,duas vezes por dia foram igualmente eficazes como tratamento anti-hipertensivo,mas a felodipina foi melhor tolerada

A parallel group randomised comparative study of felodipine and nifedipine in hypertension.

We compared the antihypertensive effects and tolerability of a new calcium channel antagonist felodipine with nifedipine in an open randomised parallel group study in 49 patients with moderate hypertension (diastolic blood pressure 105-120 mm Hg). After two weeks run in period felodipine 5 mg and 10 mg once daily was compared with nifedipine 10 mg tid for an active treatment period of 4 weeks. Twenty three patients (mean age 42 +/- 10 years) received felodipine 5 mg once daily for first 2 weeks and 10 mg once daily for subsequent 2 weeks. Twenty six patients (mean age 45 +/- 9 years) received nifedipine 10 mg tid for 4 weeks. The mean reduction in supine diastolic blood pressure in two groups was 17 +/- 6 mm Hg (nifedipine) and 19 +/- 8 mm Hg (felodipine) (p = NS). The goal diastolic blood pressure of less than or equal to 90 mm Hg was achieved in 31 percent (nifedipine group) and 43.5 percent (felodipine group) of patients (p = NS). Side effects were common with both drugs; however, the tolerability was better with felodipine than with nifedipine. In conclusion felodipine was as effective as nifedipine and had the advantage of once a day dosage.