RESUMO
We conducted an open, add-on study with topiramate (TPM) as adjunctive therapy in Lennox-Gastaut syndrome (LGS), to assess the long-term efficacy and safety and to evaluate quality of life (QL) measurements in the chronic use of TPM. We studied 19 patients (11 male; age ranging from 4 to 14 years) with uncontrolled seizures receiving 2-3 anti- epileptic drugs. Patients were followed up to 36 months of treatment. A questionnaire was used to query parents about QL. Seven patients completed the study at 36 months and seizure frequency was reduced = 75 per cent in 4, and < 50 per cent in patients. Two children became seizure free for more than 24 months. Most side effects were CNS related, with the most frequent being somnolence and anorexia. These were generally transient. One patient dropped-out due to powder in the urine. None of the patients required hospitalization. At 36 months, patients' alertness (2/7), interaction with environment (5/7), ability to perform daily activities (5/7), and verbal performance (6/7) improved on TPM. We conclude that TPM may be useful as adjunctive therapy in the treatment of LGS. The efficacy of TPM was maintained in long-term treatment in more than 40 per cent of patients, long term safety was confirmed and QL improve on TPM.
Assuntos
Feminino , Humanos , Adolescente , Pré-Escolar , Criança , Anticonvulsivantes/uso terapêutico , Epilepsia/tratamento farmacológico , Frutose/análogos & derivados , Frutose/uso terapêutico , Anticonvulsivantes/farmacocinética , Seguimentos , Frutose/farmacocinética , Resultado do TratamentoRESUMO
Los edulcorantes son productos útiles empleados muy comúnmente en la alimentación de los pacientes diabéticos y en regímenes hipocalóricos. Se presenta un análisis crítico de los diferentes edulcorantes calóricos y no calóricos actualmente disponibles en el mercado nacional analizando el aporte energético así como las ventajas y desventajas de cada uno de ellos. Se describen las características químicas y metabólicas del aspartame, endulzante no calórico y se comentan las investigaciones que se realizaron para lograr la autorización de su uso por la Federal Drug Administration (FDA). Se hace énfasis en que el profesional de la salud, debe tener conocimientos sobre los edulcorantes y productos dietéticos, a objeto de instruir a los pacientes para la correcta selección de ellos