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JPMA-Journal of Pakistan Medical Association. 1994; 44 (7): 166-169
em Inglês | IMEMR | ID: emr-33111

RESUMO

A cross-over study, comparing the effects of doxazosin, moduretic and amlodipine on plasma lipid and lipoprotein levels in 9 hypertensive Nigerians aged 35 to 65 years is presented. Doxazosin therapy had favourable lipid changes characterized by a statistically significant reduction in total cholesterol [TC] at 6 months. Though consistent reduction was observed in total triglycerides [TG] low density lipoprotein cholesterol [LDL-C], very low density lipoprotein-cholesterol [VLDLC] upto 6 months, no effect was seen on high density lipoprotein cholesterol [HDLC]. This is against unfavourable increments in the mean values of TC, VLDLC, LDLC/HDLC and decrease in HDLC/TC during moduretic treatment phase. Amlodipine therapy did not alter the lipid and lipoprotein levels. The non-significant variation in the mean high density lipoprotein-cholesterol [HDLC] level observed with these agents, seem to suggest that HDL-cholesterol metabolism may be maintained during antihypertensive pharmacotherapy


Assuntos
Humanos , Lipoproteínas/ultraestrutura , Lipídeos/sangue , Colesterol/sangue , /farmacologia
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