RESUMO
A method was evaluated for determination of twenty-one doping (including nandrolone, boldenone and methandienone) in human urine by gas chromatography-high resolution mass spectrometry. Samples were prepared by liquid-liquid extraction, concentrated, TMS derivatization and limit of detection at ng x mL(-1) by MID/GC/HRMS. According to the code of the World Anti-Doping Agency (WADA), precision and recoveries of the procedure were evaluated by replicate analysis (n = 6), the recoveries in the range of 66%-103%, with the RSD below 10.0%. The precision within the day of the method with three different concentrations was also determined RSD were less than 9.5%, 10.0% and 9.7%.
Assuntos
Humanos , Anabolizantes , Urina , Dopagem Esportivo , Cromatografia Gasosa-Espectrometria de Massas , Metandrostenolona , Urina , Nandrolona , Urina , Detecção do Abuso de Substâncias , Métodos , Testosterona , UrinaRESUMO
The influence of anabolic steroid on the process of production of rickets in vitamin-D deficient animals as well as its influence on healing of rickets with vitamin-D therapy was studied. Long-Evans strains of female rats of two age groups (6 weeks and 4 weeks) were given rachitogenic diet and were divided into five sub-groups-(I) control receiving vitamin-D from the 1st day, (II) rachitic group, (III) receiving vitamin-D from 36th day, (IV) receiving anabolic hormone from the beginning of the experiment and (V) receiving both vitamin-D and anabolic hormone from 36th day of treatment. It was observed grossly as well as histologically and radiographically that: (1) the anabolic steroid minimizes the rachitic changes in the bones of vitamin-D deficient rats, (2) in rachitic animals, a combination therapy of anabolic hormone and vitamin-D results in comparatively greater calcification of osteoid matrix and better healing and remodelling of bone than with vitamin-D alone.
Assuntos
Animais , Quimioterapia Combinada , Epífises/patologia , Feminino , Metandrostenolona/uso terapêutico , Ratos , Raquitismo/tratamento farmacológico , Tíbia/patologia , Vitamina D/uso terapêuticoAssuntos
Adolescente , Adulto , Antropometria , Apetite , Braço/anatomia & histologia , Pressão Sanguínea , Peso Corporal/efeitos dos fármacos , Seguimentos , Humanos , Masculino , Metandrostenolona/farmacologia , Esforço Físico , Pulso Arterial , Dobras Cutâneas , Coxa da Perna/anatomia & histologiaAssuntos
Humanos , Masculino , Feminino , Metandrostenolona , Resultado do Tratamento , Degeneração MacularRESUMO
Se presenta un paciente de seis años de edad, afectado de anemia hipoplástica congénita. Se efectúa un análisis de la etiopatogenia, diagnóstico, pronóstico y de las posibilidades terapéuticas.