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Indian J Exp Biol ; 1989 May; 27(5): 437-41
Artigo em Inglês | IMSEAR | ID: sea-58996

RESUMO

V-79 cells when exposed to thymidine (5 micrograms/ml) in growth medium after treatment with X-rays, UV light and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), responded differently depending upon the agent. For treatment with X-rays and UV light, only induction of mutation was potentiated, but for MNNG treatment, both killing and mutation induction were potentiated. The increase in killing of MNNG exposed cells could be reversed by simultaneous addition of deoxycytidine with thymidine, but, for all the three mutagenic treatments, enhancement in mutation induction could not be suppressed by deoxycytidine.


Assuntos
Animais , Linhagem Celular , Sobrevivência Celular/efeitos dos fármacos , Cricetinae , Cricetulus , Masculino , Metilnitronitrosoguanidina/farmacologia , Mutação , Timidina/farmacologia , Raios Ultravioleta
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