1.
Braz. j. med. biol. res
;
21(3): 577-83, Mar. 1988. ilus
Artigo
em Inglês
| LILACS
| ID: lil-60268
RESUMO
Morphine and nalorphine were shown to have a peripheral effect on conscious guinea pigs, producing a decrease in the vocalization response to noxious electrical stimulation. Naloxone antagonized the effect of morphine and nalorphine. Locally administered clonidine had a peripheral effect on conscious guinea pigs, producing a decrease in the vocalization response to noxious electrical stimulation. The peripheral analgesia of clonidine was antagonized by yohimbine and naloxone. The analgesic effect clonidine was 250-300 times more potent than that of lidocaine. It is suggested that alfa2-adrenergic receptor agonists may active enkephalin-like substances released at the peripheral level
Assuntos
Cobaias , Animais , Analgesia , Clonidina/administração & dosagem , Relação Dose-Resposta a Droga , Estimulação Elétrica , Injeções Subcutâneas , Morfina/administração & dosagem , Nalorfina/administração & dosagem , Medição da Dor , Vocalização Animal
2.
Southeast Asian J Trop Med Public Health
;
1973 Dec; 4(4): 593-5
Artigo
em Inglês
| IMSEAR
| ID: sea-34258