RESUMO
PURPOSE: To investigate de adjunctive effect of Hyperbaric Oxygen Therapy in a group of patients with refractory Crohn's disease. METHODS: A total of 29 subjects with refractory Crohn's disease were submitted to daily sessions of Hyperbaric Oxygen Therapy, in a 2800 Sechrist Monoplace Hyperbaric Chamber (Sechrist, USA) pressurized to 2.4 ATA. Each session lasted 2 hours. The endpoint was closure of enterocutaneous fistulas and complete healing of Pyoderma Gangrenosum and perineal Crohn's disease. RESULTS: A total of 829 HBOT sessions were performed and no complications were noted. Overall success rate was 76% (22 cases). Pyoderma Gangrenosum and enterocutaneous fistulas had the highest successful healing rates (100% and 91%, respectively). Perineal Crohn's disease healing rate was 65%. CONCLUSION: Adjunctive Hyperbaric Oxygen Therapy promoted satisfactory healing in a group of patients with refractory Crohn's disease.
Assuntos
Humanos , Masculino , Criança , Adulto , Pessoa de Meia-Idade , Idoso , Adulto Jovem , Cicatrização , Doença de Crohn/terapia , Fístula Intestinal/terapia , Pioderma Gangrenoso/terapia , Oxigenoterapia Hiperbárica/métodos , Fatores de Tempo , Estudos Prospectivos , Reprodutibilidade dos Testes , Resultado do Tratamento , Terapia Combinada , Oxigenoterapia Hiperbárica/estatística & dados numéricosRESUMO
Estudo retrospectivo de 1506 pacientes com lesões teciduais agudas e crônicas, submetidos a tratamento mínimo efetivo com OHB. A mortalidade foi de 5,24 por cento, menor que a de 21,26 por cento, do grupo geral de pacientes de OHB (p < 0.001). A maioria dos óbitos ocorreu antes de atingir o tratamento mínimo efetivo. Pacientes agudos necessitaram de 11 a 18 sessões e crônicos 30 sessões (p< 0,001) para a cura./Retrospective study of 1506 patients with acute and chronic tissue lesions with minimun effective HBO treatment...