Efficacy and mechanism of traditional chinese medicine gel in sports-related soft tissue injury / Eficácia e mecanismo do tradicional gel da medicina chinesa em lesões desportivas de tecidos moles / Eficacia y mecanismo del gel de medicina tradicional china en lesiones deportivas de tejidos blandos

ABSTRACT Soft tissue injury is the most common disease in orthopedics, and it is also the most easily neglected disease in sports. Without timely and effective treatment, it is easy to develop into malignant strain and seriously affect life and sports. In view of this, the aim of this study is to analyze the effect and mechanism of traditional Chinese medicine gel in treating such injuries in the light of the characteristics of sports-related soft tissue injury. The right gastrocnemius muscle injury was simulated in 36 adult male rats. Chinese medicine gel and tincture were used to treat it. The contents of interleukin, alanine aminotransferase, blood urea nitrogen and prostaglandin E2 in the blood of rats under different courses of treatment were analyzed to explore recovery in four rats. The results showed that the levels of interleukin and prostaglandin E2 in the blood of rats treated with drugs were significantly lower than those in the control group (p<0.05), indicating that both drugs have obvious therapeutic effects on soft tissue injury. The content of interleukin in the blood of the Chinese medicine gel group was slightly lower than that of the tincture group, indicating that the Chinese medicine gel could affect the recovery of soft tissue injury by affecting leukocyte interleukin. This result is helpful in the treatment of soft tissue injury in sports and to further improve the therapeutic effect of traditional Chinese medicine gel.

RESUMO A lesão dos tecidos moles é a doença mais comum na ortopedia, e é também a doença mais facilmente negligenciada nos esportes. Sem tratamento ágil e eficaz, facilmente evolui para luxações malignas, afetando seriamente a vida e a prática de esportes. Em vista disso, o objetivo deste estudo é analisar o efeito e o mecanismo do gel da medicina tradicional chinesa no tratamento de tais lesões, com base nas características da lesão dos tecidos moles relacionada à prática esportiva. Estimulou-se lesão do músculo gastrocnêmio direito em 36 ratos adultos. O gel e a tintura chinesa foram usados para o tratamento. Foram analisados os conteúdos de interleucina, alanina aminotransferase, ureia sanguínea azoto e prostaglandina E2 no sangue dos ratos sob diferentes tratamentos, de modo a explorar a recuperação de quatro ratos. Os resultados mostraram que os níveis de interleucina e prostaglandina E2 no sangue dos ratos tratados com medicamentos eram significativamente inferiores aos do grupo controle (p<0.05), indicando que ambos os fármacos têm efeitos terapêuticos óbvios sobre lesões dos tecidos moles. O teor de interleucina no sangue do grupo gel chinês medicinal mostrou-se ligeiramente inferior ao do grupo tintura, indicando que o gel medicinal chinês pode afetar a recuperação da lesão nos tecidos moles, afetando o leucócito interleucina. Este resultado é útil para o tratamento de lesões dos tecidos moles relacionadas à prática esportiva e para melhorar ainda mais o efeito terapêutico do gel da medicina chinesa tradicional.

RESUMEN La lesión de los tejidos blandos es la enfermedad más común en la ortopedia, y es también la enfermedad más fácilmente descuidada en los deportes. Sin tratamiento ágil y eficaz, fácilmente evolucionan a luxaciones malignas, afectando seriamente la vida y la práctica de deportes. En vista de eso, el objetivo de este estudio es analizar el efecto y el mecanismo del gel de la medicina tradicional china en el tratamiento de tales lesiones, con base en las características de la lesión de los tejidos blandos relacionada a la práctica deportiva. Se estimuló lesión del músculo gastrocnemio derecho en 36 ratones adultos. El gel y la tintura china fueron usados para el tratamiento. Fueron analizados los contenidos de interleucina, alanina aminotransferasa, urea sanguínea, nitrógeno y prostaglandina E2 en la sangre de los ratones bajo diferentes tratamientos, de modo de explorar la recuperación de cuatro ratones. Los resultados mostraron que los niveles de interleucina y prostaglandina E2 en la sangre de los ratones tratados con medicamentos eran significativamente inferiores a los del grupo control (p<0.05), indicando que ambos fármacos tienen efectos terapéuticos obvios sobre lesiones de los tejidos blandos. El tenor de interleucina en la sangre del grupo gel chino medicinal se mostró ligeramente inferior al del grupo tintura, indicando que el gel medicinal chino puede afectar la recuperación de la lesión en los tejidos blandos, afectando el leucocito interleucina. Este resultado es útil para el tratamiento de lesiones de los tejidos blandos relacionadas a la práctica deportiva y para mejorar aún más el efecto terapéutico del gel de la medicina china tradicional.

Efeito do extrato de Bidens pilosa L, Mel e pomadas homeopática e alopática na cicatrização de feridas cutâneas de ratos Wistar / [Effect of Bidens pilosa L, Honey extract and homeopathic and allopathic ointments on the healing of skin wounds of Wistar rats]

Cicatrização de ferida é um processo dinâmico, que tem por objetivo restaurar a continuidade do tecido lesionado. No entanto, em alguns casos, é necessário favorecer condições adequadas para viabilizar o processo fisiológico. Neste estudo foram utilizados ratos Wistar, divididos aleatoriamente entre cinco grupos, com 12 animais cada, sendo eles: grupo P (Bidens pilosa L.), grupo mel, grupo Co1 (pomada comercial alopática), grupo Co2 (pomada comercial homeopática) e grupo CT (controle). As lesões foram geradas por incisão com punch de 8mm, sendo tratadas diariamente de forma tópica. Foram eutanasiados quatro animais por grupo, no terceiro, sétimo e 14º dias do experimento, e o material coletado foi armazenado em formalina 10% e encaminhado para processamento histológico. Posteriormente, realizou-se a contagem de leucócitos mononucleares, fibroblastos e neovasos e avaliou-se a arquitetura de fibras colágenas. Os resultados da contagem foram analisados pela ANOVA, seguida pelo teste de Tukey (P<0,05). O modelo experimental proposto neste estudo demonstrou que todos os tratamentos apresentaram potencial cicatrizante, com exceção do mel. A aplicação tópica do creme do extrato de Bidens pilosa L. a 10% apresentou melhor perfil anti-inflamatório; a pomada alopática apresentou boa aderência à superfície da lesão e a pomada homeopática, grande potencial angiogênico, com menor tempo de cicatrização.(AU)

Wound healing is a dynamic process that aims to restore the continuity of injured tissue. However, in some cases it is necessary to favor adequate conditions to enable the physiological process. Wistar rats were randomly divided into 5 groups with 12 animals each, namely: group P (Bidens pilosa L.), group honey, group Co1 (commercial allopathic ointment), group Co2 (commercial homeopathic ointment) and group CT (control). The lesions were generated by an 8mm punch incision and were treated topically daily. Four animals per group were euthanized on the 3rd, 7th and 14th day of the experiment and the collected material was stored in 10% formalin and sent for histological processing, after which mononuclear, fibroblasts and neovascular leukocytes were counted and collagen fiber architecture was evaluated. Counting results were analyzed by ANOVA, followed by Tukey test (p <0.05). The experimental model proposed in this study showed that all treatments had healing potential, except honey. The topical application of 10% Bidens pilosa L. extract cream showed the best anti-inflammatory profile; Allopathic ointment showed good adhesion to the surface of the lesion and homeopathic ointment showed great angiogenic potential with shorter healing time.(AU)

Morphological changes in the tissue structures afeter thermal burns on the background of using dermarm wound dressing

Over the last decade, the interest in using bacterial cellulose in medicine has increased. The article publishes the data about the efficiency of healing burn wounds in rabbits in experimental conditions with the use of the DermaRM wound dressing, compared to the traditionally used Panthenol ointment and the Branolind N salve dressing

Development and evaluation of the efficiency of ointment for cheilitis treatment in patients with dental and jaw anomalies

Cheilitis is a group of chronic diseases of the vermilion border that are diverse in etiology, pathogenesis and clinical picture. The development of various forms of cheilitis is facilitated by defects of the architectonics of the lips, unhealthy lifestyle, anatomical features of the lip structure, adverse meteorological effects, decrease in specific and non-specific factors for protecting the oral cavity, the patient's psycho-emotional state, immuno-allergic factors and accompanying general somatic and dental pathologies. The issues of prevention and comprehensive treatment of lip diseases are especially relevant in dental practice. The article presents data on the prevalence of cheilitis and dentoalveolar anomalies and the need for their treatment in young people. Furthermore, the authors provide a composition justification and develop an ointment for the treatment of cheilitis in this category of patients.

Selección y evaluación de tecnologías sanitarias: trolamina / Selection and evaluation of health technologies: trolamina

La UDR-Lambayeque autoriza la cobertura de Trolamina 0,67 g tubo por 93g emulsión tópica para los diagnósticos solicitados: úlcera cutánea no infectada aguda y crónica, quemaduras de primer y segundo grado, úlcera de presión y úlceras post-traumática, solicitada por la IPRESS Hospital Regional Lambayeque.(AU)

Analysis of the rate of maturogenesis of a traumatized Cvek’s stage 3 anterior tooth treated with platelet‑rich fibrinas a regenerative tool using three‑dimensional cone‑beam computed tomography: An original case report.

Regenerative endodontic procedures are biologically based procedures which deal with the regeneration of pulp‑like tissue, more idealistically the pulp‑dentin complex. The regeneration of this pulp‑dentin complex in an infected necrotic tooth with an open apex is possible only when the canal is effectively disinfected. Though there are various procedures for treating open apex ranging from Ca(OH) 2 apexification, mineral trioxide aggregate apexification and surgical approach, regeneration of tissues has always taken superior hand over the repair of tissues. The mechanics behind the regenerative endodontic procedures is that despite the tooth being necrotic, some pulp tissue can survive apically which under favorable conditions proliferate to aid in the process of regeneration. In the past 2 decades, an increased understanding of the physiological roles of platelets in wound healing and after tissue injury has led to the idea of using platelets as therapeutic tools in the field regenerative endodontics. In the present case report with an open apex, high sterilization protocol is followed using triple antibiotic paste as intra‑canal medicament, followed which platelet rich fibrin is used as the regenerative material of choice. Over an 18‑month follow‑up period, clinically patient is asymptomatic and radiographically there is complete regression of the periapical lesion and initiation of the root end closure.

Current Practice Pattern for Dry Eye Patients in South Korea: A Multicenter Study

PURPOSE: To assess current practice patterns for dry eye patients in South Korea and to evaluate the preference according to the ages and clinic types of physicians. METHODS: Dry eye patients (n = 1,612) were enrolled in this multicenter cross-sectional, observational study. The severity level of dry eye patients was classified based on the Korean guidelines for dry eye treatment. The medical records of the enrolled dry eye patients were evaluated, and the practice styles and the preferences were analyzed according to the ages and clinic types of physicians. RESULTS: Of all patients, dry eye level 1 was most common (47.5%), followed by level 2 (33.5%), level 3 (9.1%), and level 4 (1.1%). Topical anti-inflammatory agents were used in 70.7% of patients with dry eye level 2 and in 80.6% of patients at levels 3 and 4. Topical anti-inflammatory agents were also used in 48.7% of patients with dry eye level 1. Preservative-free artificial tears were preferred at all dry eye levels. The use of topical anti-inflammatory agents did not differ with investigator ages, but older physicians preferred preserved artificial tears more than younger ones. Physicians at referral hospitals also tended to use topical anti-inflammatory agents and preservative-free artificial tears earlier, beginning at dry eye level 1, than those who worked at private eye clinics. CONCLUSIONS: Topical anti-inflammatory agents were commonly prescribed for the treatment of dry eye patients in South Korea, even from dry eye level 1. Preservative-free artificial tears were preferred at all dry eye levels. Practice styles differed somewhat depending on the ages and clinic types of physicians.

Clinical Trial Comparing Efficacy and Safety of Ornidazole 1% and Povidone Iodine 5% Fixed Dose Combination Ointment with Povidone Iodine 5% Formulation and Ornidazole 1% Formulation for Prevention or Treatment of Surgical Wounds.

Aim: This trial is undertaken to evaluate the efficacy and safety of this FDC ointment for post-surgical patient management. This multi-centre, prospective, randomized, comparative, open-labeled, three-arm parallel group study involving 180 patients was conducted in patients with surgical wound. The trial was conducted at 2 centres and had 90 patients completed at each center. Methods: Patients were in randomized in three groups, to receive either the study formulation of Ornidazole 1% - Povidone iodine 5% FDC ointment (Group I ) or Povidone iodine 5% Ointment (Group II) or Ornidazole 1% Ointment (Group III). These ointments were applied for post surgical wound care. Dressing was done twice daily till the discharge of patients (Day 5-7). Patients were asked to use respective ointment for wound dressings after discharge. The patients were assessed for clinical wound improvement by using the Bates Jensen Wound Assessment Tool (BWATS). General and systemic examination was done at every visit of the patient. Results: Reduction in wound size was significant in all three groups from day 1 onwards. In group I exudates amount improved significantly from day 5 as compared to day 3, in Group II and Group III the improvement was from Day 8 onwards as compared to day 5. Peripheral tissue edema and Peripheral Tissue Induration improved in Group I and as compared to baseline. Epithelialization was statistically better in Group I and Group II from day 1 compared to baseline and in Group III it improved from day 5. No adverse event were seen in any of the groups. Conclusion: We concluded that the combination was better as compared to each individual drug in prevention of wound infection and promoting wound healing.

Assessment of Efficacy and Safety of Fixed Dose Combination of 3% Biophytex LS 8740 and 5% Proteasyl TP LS 8657 Cream in the Treatment of Under Eye Dark Circles (Infra-orbital Hyperchromia).

Background: Under Eye Dark Circles is attributed to multiple factors. The treatment should address the various pathologies involved to provide the best possible effects. Aims: To assess the efficacy and safety of Wunder eye cream (a combination of 3% Biophytex LS 8740 and 5% Proteasyl TP LS 8657) in patients with under eye dark circles. Study Design: Open label, prospective, single arm and multicentric post marketing surveillance clinical study. Materials and Methods: 142 patients (125 males and 17 females) were evaluated in the study. Wunder Eye cream was applied twice daily on the affected under eye dark circle area for eight weeks. Parameters evaluated were area of under eye pigmentation, improvement in luminance of under eye skin, reduction in under eye puffiness and reduction in under eye wrinkles using a digital camera photographs after four and eight weeks of treatment. Safety evaluation was also done on the same time. The values were compared using Chi-Square test. Results: Early response was seen in 40% of patients with four weeks of treatment where 50% improvement in all the parameters was seen. With eight weeks of therapy about 92.3% of patients showed 50 to 100% improvement in the area of under eye pigmentation; 50% to 75% improvement was seen in 87.3% of patients for under eye pigmentation, in 80.1% patients for luminance of under eye skin, in 68% patients for under eye puffiness and in 67.4% of patients for under eye wrinkles. Conclusion: Wunder eye cream is a combination of botanical and yeast extracts was found to be effective against under eye dark circles.

Efecto cicatrizante de la pasta de clorofila-caroteno de Pinus caribaea var caribaea sobre heridas abiertas asépticas / Healing effect of Pinus caribaea var caribaea paste on aseptic open wounds

Introducción: la cicatrización de heridas es un problema de salud de gran relevancia en la práctica médica actual. Diversos tratamientos en su curación se proponen, entre ellos la aplicación de plantas medicinales. El follaje de Pinus caribaea var. caribaea presenta una variada composición química y es una planta forestal de abundancia en Cuba. Objetivo: evaluar la actividad cicatrizante de la pasta de clorofila-caroteno obtenida a partir del follaje de P. caribaea en un modelo de heridas abiertas en ratas, empleando como controles positivos dos formulaciones de acción cicatrizante comprobada de Rhizophora mangle L. Métodos: se utilizaron 16 ratas Wistar de los 2 sexos, en 4 grupos de 4 ratas cada uno, a las cuales se les provocó heridas. En el grupo control se realizó la administración tópica de vehículo (agua estéril), y en los 3 restantes, pasta de clorofila-caroteno, CIKRON y gel de R. mangle, diariamente durante 11 d. Se procedió a la medición del área de las heridas en el día inicial, a los 8 y 11 d; además, se hizo la evaluación clínica del estado de los animales y se sacrificaron al final del experimento, con el estudio histopatológico de la piel. La evaluación estadística se procesó por análisis de varianza, comparación múltiple de Duncan y chi cuadrado. Resultados: se comprobó el efecto cicatrizante de la pasta de clorofila-caroteno, al disminuir el área de las heridas de manera significativa respecto al resto de los grupos en los días 8 y 11, así como no se manifestaron signos clínicos...

Introduction: wound healing is a significant healthcare problem in today's medical practice. Several courses of treatment are suggested for healing, including the use of medicinal plants. The green foliage of Pinus caribaea var. caribaea, an abundant plant in Cuba, presents varied chemical composition. Objective: to evaluate wound healing activity of chlorophyll carotene paste from green foliage of Pinus caribaea var. caribaea in open wounds in rats, using two Rhizophora mangle L. formulations with proved wound healing effect as positive controls. Methods: Wistar rats of both sexes, distributed into 4 groups of 4 rats each, were used and they were intentionally wounded. In the control group, the sterile water as vehicle was topically administered where in the other 3 groups, the chlorophyll carotene paste, CIKRON and gel from R. mangle were daily applied for 11 days. The wound area was measured on the first day, 8th and 11th days; in addition to clinical evaluation of the condition of the rats, which were slaughtered at the end of the experiment. A histopathological study was conducted with their skin. The statistical exaluation was based on variance analysis, Duncanïs multiple comparison and chi square. Results: the healing effect of chlorophyll-carotene paste was significant since the wound areas were substantially reduced at 8th and 11th days and clinical signs did not appear. The histological study revealed a high percentage of wounds in healing Phase II of the epidermis and dermis in all the groups. The group treated with chlorophyll-carotene paste showed the greatest portion of histological parameters in healing phases I and II with respect to the rest of the groups. Conclusions: the favourable effect of chlorophyll carotene paste from green foliage of Pinus caribaea var. caribaea in the open wound healing was demonstrated, which is comparable to that of the drugs from Rhizophora mangle L

Dermatofilosis humana y animal. Presentación de un caso atípico y revisión de la literatura / Human and animal dermatophilosis. An unusual case report and review of the literature

La dermatofilosis es una infección causada por una bacteria Gram positiva perteneciente al orden de los Actinomycetales, llamada Dermatophilus congolensis. Se presenta como una dermatosis de carácter agudo, subagudo o crónico que afecta preferentemente al ganado pero también a una amplia variedad de animales domésticos y salvajes y al hombre. Tiene distribución universal, pero con mayor prevalencia en climas húmedos, tropicales y subtropicales. Es considerada una zoonosis menor que puede causar grandes perjuicios económicos en la industria del ganado y el cuero. Se realiza una revisión del tema junto con la presentación de un caso clínico sumamente atípico.

Dermatophilosis is an acute, subacute or chronic skin disease affecting a wide range of species of animals and man. It is caused by a Gram (+) bacteria of the order of the Actinomycetales named Dermatophilus congolensis. Presenting as an acute, subacute or chronic dermatosis affecting primarily cattle, but a wide variety of domestic and wild animals, and humans, as well. It is distributed worldwide but more prevalent in the humid tropical and subtropic areas. It is essential to emphasize the importance of this disease in livestock industry and leather production. The disease is reviewed and an unusual case is reported.

Pityriasis rubra pilaris: presentación de casos / Pityriasis rubra pilaris: presentation of cases

Se realizó una presentación de casos, de dos pacientes con lesiones dermatológicas, donde existe correlación clínico-histopatológica, de Pityriasis rubra pilaris. La intención de este trabajo es que en la práctica dermatológica se piense en esta dermatosis. Para ello se tuvieron como objetivos: viabilizar la comprensión de esta entidad, contribuir a realizar el diagnóstico diferencial con otros cuadros como son dermatitis seborreica, queratodermia palmo-plantar, psoriasis, entre otros. En la dermatosis objeto de estudio, su cuadro histológico es característico, y debe introducirse alimentos en la dieta ricos en vitamina A, beta carotenos y azufre, pues el factor alimenticio juega un papel importante en aquellas afecciones donde la etiología por déficit de las vitaminas u otro oligoelemento está presente. Se revisan aspectos clínicos, asociaciones con otras enfermedades, el tratamiento de esta dermatosis. Se utilizó el método aleatorio, al azar, longitudinal, corroborando el diagnóstico por biopsia de piel de las pacientes. Las pacientes estudiados fueron: ARG, de 5 años, femenina, blanca remitida por el pediatra por lesiones en placas máculo amarillo-hipocrómicas–papulosas, distribuidas en superficie de extensión de brazos y piernas; LSG, de 19 años, femenina, blanca, que es remitida por presentar lesiones en placas máculo-hipocrómico pápulo-escamosas bordes difusos, localizadas en muslo y pierna derechos, se constata alopecia difusa del pelo del cuero cabelludo. El tratamiento local indicado fue una pomada con reductor, ácido salicílico y vaselina, la orientación alimenticia fue dirigida a ingerir alimentos ricos en vitamina A o beta carotenos, y alimentos ricos en azufre, insistiéndoles en esta parte del tratamiento por los antecedentes de ambas pacientes a la no ingestión de estos alimentos. A lo largo de 10 años hemos revisado anualmente la evolución de las pacientes, no existiendo recidivas hasta el momento, manteniendo ambas el régimen dietético orientado.

We presented the cases of two patients with dermatologic lesions, where there it is clinic- histopathologic correlation, of Pityriasis rubra pilaris. The intention of this work is taking into account this dermatosis in the dermatologic practice. To achieve that our objectives were: allowing the comprehension of this entity, contributing to the differential diagnosis with other conditions like seborrheic dermatitis, palmoplantar keratoderma, psoriasis and others. The histological picture of the studied dermatosis is characteristic, and there should be introduced in the diet foods rich in vitamin A, beta carotenes and sulfur, because the alimentary fact plays an important role in those conditions where the etiology by vitamins or other oligo-element deficit is present. We reviewed clinical aspects, the association with other diseases, the treatment of this dermatosis. We used the randomized, longitudinal method, corroborating the diagnostic by patient's skin biopsy. The studied patients were: ARG, white, female, 5-years-old patient send by the podiatrist because she had lesions in yellow macula hypochromic- papular plates, located in extension surfaces of arms and legs; LSG, white, female, 19-years-old patient send presenting lesions in macula- hypochromic papular- squamous plaques with diffuse rims, located in the right thigh and leg, stating diffuse alopecia of the scalp. The indicated treatment was an ointment with reductive, salicylic acid and vaseline. They were advised to eat foods rich in vitamin A or beta carotenes and sulfur, insisting in this part of the treatment because they had antecedents of not eating these foods. We have followed the evolution of these patients for ten years without relapses, having the patients kept the oriented dietetic regime.

Efectividad de la pomada de urea en las verrugas plantares / Effectiveness of the urea ointment in the feet warts

Se hizo un ensayo clinicoterapéutico en 60 pacientes atendidos en la consulta de Dermatología del Hospital Provincial Docente Dr Joaquín Castillo Duany de Santiago de Cuba, durante el 2008, con el fin evaluar la efectividad de la pomada de urea en las verrugas plantares. Se conformaron 2 grupos (de estudio y control): los primeros recibieron pomada de urea al 20 por ciento y los segundos pomada salicílica al 40 por ciento. La pomada de urea resultó más eficaz para eliminar las manifestaciones clínicas de esa lesión, en un período de 6 a 8 semanas y no hubo reacciones adversas.

A clinical therapeutical trial was made in 60 patients assisted at the Dermatology department of Dr Joaquín Castillo Duany Teaching Provincial Hospital from Santiago de Cuba, during 2008, aimed at evaluating the effectiveness of the urea ointment in the feet warts. They conformed to 2 groups (study and control): the first group received urea ointment at 20 percent and the second one salicylic ointment at 40 percent. The urea ointment was more effective to eliminate the clinical manifestations of that lesion, in a period of 6 to 8 weeks and there were not adverse reactions.

Comparison of internal sphincterotomy with topical diltiazem for post-hemorrhoidectomy pain relief: a prospective randomized trial.

AIM: To assess the efficacy of internal sphincterotomy compared with application of topical 2% Diltiazem ointment after hemorrhoidectomy for pain relief. SETTINGS AND DESIGN: Prospective randomized study. MATERIALS AND METHODS: In an 18-month period, 108 subjects with uncomplicated Grade 3/ 4 hemorrhoids were enrolled in the study and were randomized into two equal groups: Subjects in Group A underwent internal sphincterotomy at time of primary surgery while those in Group B received 1 g of 2% Diltiazem ointment locally, thrice daily for seven days. Postoperative pain perception was measured using visual analog score (VAS) and on the basis of number of analgesic tablets (Tab tramadol 50 mg) required in each group. Time to discharge, time to return to work and incidence of complications measured and compared. STATISTICAL ANALYSIS USED: Statistical techniques applied were Student T test, Chi-square and Fisher's Exact Test. RESULTS: There were 102 analyzable subjects (Group A: 50 and Group B: 52). The mean VAS score was significantly less in the internal sphincterotomy group from the fourth postoperative day onwards compared to topical Diltiazem (2.23 vs. 3.72; P =0.031). Similarly, the mean requirement of analgesic tablets [10.54 vs. 15.40; P =0.01] was much lower in Group A. There was no significant difference in terms of time to discharge and time to return to work between the two groups. The incidence of complications was more with the internal sphincterotomy group (11.5% vs. 3 %; P =0.488). CONCLUSIONS: In patients undergoing hemorrhoidectomy, addition of surgical internal sphincterotomy results in lesser pain in the postoperative period as compared to those receiving topical application of Diltiazem.

Estudio de vida útil del ungüento QL / Useful life study of QL ointment

El ungüento QL es un nuevo medicamento en fase de desarrollo destinado al tratamiento del brote hemorroidal agudo. Para su introducción en la terapéutica es indispensable comprobar su estabilidad física y química. Los estudios de vida útil se realizaron según las exigencias actuales, para lo cual se analizaron 3 lotes pilotos QL01, QL02 y QL03, almacenados a temperatura ambiente, de refrigeración y temperatura controlada. Los estudios se realizaron a tiempo 0, 1, 2, 3, 6 y 12 meses. No se observaron cambios en las propiedades organolépticas ni en el área de extensibilidad. Se mantuvo el flujo pseudoplástico tixotrópico característico de este tipo de sistema al cabo de los 6 meses. Los principios activos: quitina y clorhidrato de lidocaína, se mantuvieron estables en el tiempo para todas las condiciones de almacenamiento evaluadas.

QL ointment is a new drug under development stage used to treat the acute hemorrhoidal outbreak. To introduce it in the therapeutics,it is necessary to prove its physical and chemical stability. The useful life studies were conducted according to the current demands. To this end, 3 pilot batches, QL01, QL02 y QL03, stored at room temperature at controlled refrigeration and temperature, were analyzed. The studies were undertaken at 0, 1, 2, 3, 6, and 12 months. No changes were observed neither in the organoleptic properties, nor in the extensibility area. The pseudoplastic tixotropic flow characteristic of this type of system was maintained at 6 months. The active principles chitin and lidocaine chlorhydrate were steady in time for all the storing conditions evaluated.

Tratamiento tópico de la escabiosis con azufre precipitado en petrolato, en escolares de Coro, Estado Falcón, Venezuela / Topical treatment with precipitated sulphur petrolatum for school aged children scabies from coro, Falcon State, Venezuela

Entre Marzo-Junio de 2003, se ha llevado a cabo un estudio descriptivo y transversal controlado para evaluar la eficacia, seguridad, aceptación y tolerancia del ungüento azufre precipitado en petrolato (2,5%) en 71 escolares con signos y síntomas sugestivos de escabiosis, provenientes de Coro, Estado Falcón, Venezuela. El diagnóstico se hizo mediante datos anamnésicos y clínicos, y raspado de lesiones, procesándose microscópicamente con KOH (10%). El ungüento se aplicó a 1 dosis diaria durante 8 horas por 2 días, con 2 semanas de reposo, repitiéndose la dosis durante otros 2 días, retirándose la mezcla con jabón neutro y usando crema lubricante. La evaluación de la eficacia se realizó mediante cuantificación y raspado de las lesiones cutáneas y escala analógica visual (VAS) de prurito, al cabo de 7 - 30 días después de haberse finalizado la aplicación tópica. La valoración de los efectos colaterales se hizo por anamnesis y observaciones del médico. Todos los 71 niños presentaron escabiosis, y concluyeron el tratamiento, con una eficacia terapéutica del 100%, registrándose una reducción altamente significativa (p < 0,0001) al término del tratamiento del número promedio de lesiones (t =12,83; 231,14 vs 0) y VAS de prurito (t = 13,58; 39,7 vs 0,20). No se documentaron recidivas ni efectos adversos severos, siendo la tolerancia y aceptación satisfactoria. El ungüento azufre precipitado en petrolato al 2,5% es una herramienta quimioterapéutica eficaz, segura, de fácil acceso y aplicación, de tolerancia y aceptabilidad satisfactoria, y de bajos costos para el tratamiento tópico de la escabiosis infantil en los países en desarrollo.

Influência do sexo de indivíduos da mesma colônia no controle químico das populações do morcego hematófago Desmodus rotundus (Phyllostomidae) no estado de São Paulo / Influence of sex differences in the same colony for chemical control of vampire Desmodus rotundus (Phyllostomidae) populations in the state of São Paulo, Brazil

Os objetivos do presente trabalho foram estudar a fidelidade ao abrigo diurno por indivíduos de ambos os sexos da espécie Desmodus rotundus e verificar a eficácia da ação da pasta vampiricida 2 por cento na redução do tamanho de suas colônias no estado de São Paulo, por meio de estudo experimental de campo. Durante os anos de 1999 e 2000, 626 morcegos distribuídos em 12 abrigos foram capturados com redes-de-espera (armadas durante a noite) e marcados. Em seguida, 10 por cento da população previamente estimada recebeu a pasta vampiricida. No Experimento I foram tratados apenas machos, no Experimento II apenas fêmeas e no Experimento III, 5 por cento dos machos e 5 por cento das fêmeas foram tratados. Após 5 e 10 dias, foram feitas contagens dos morcegos que sobreviveram e morreram. As fêmeas mostraram-se mais fiéis aos abrigos (p<0,01) e melhores disseminadoras de pasta vampiricida (p<0,01).

Intoxicación por paraquat: toxicidad sistémica después de exposición cutánea / Paraquat poisoning: systemic toxicity after dermal exposure

La ingestión del Paraquat (dicloruro de 1,1 dimetil-4,4 dipiridilio) es el caso más común de la intoxicación fatal por plaguicidas, pero no se debe descartar la posibilidad de otras vías que lleven a un daño multiorgánico, como es el caso de la absorción dérmica del Paraquat. Nosotros reportamos el caso de un agricultor quien desarrollo daño renal y hepático después de una exposición aguda de la piel escrotal con el herbicida Paraquat con recuperación eventual del paciente. Este caso demuestra que la exposición dérmica por Paraquat, especialmente del escroto, puede producir seria toxicidad sistémica; siendo el primer caso reportado en 5 años en nuestro Instituto de toxicidad sistémica por contacto cutáneo de este químico. Se debe tomar estricta precaución, incluyendo el uso de ropa protectora siempre que se va a usar este químico.

Tolerancia y eficacia de calcipotriol ungüento en niños de 2 a 14 años con psoriasis vulgar / Tolerance and efficacy of calpotriol ointment in psoriasis vulgaris in children aged 2 - 14 años

El calcipotriol, un análogo de la vitamina D, es un tratamiento eficaz y seguro para la psoriasis en placas de carácter leve a moderado en pacientes adultos. Objetivos: Evaluar la eficacia y tolerancia del ungüento de calcipotriol en el tratamiento tópico de la psoriasis en niños. Determinar la influencia del mismo sobre el metabolismo cálcico y la presencia de efectos adversos. Materiales y métodos: 14 niños con psoriasis vulgar con menos del 30% de superficie corporal comprometida fueron tratados durante 8 semanas con calcipotriol ungüento 2 veces por día. Se evaluaron clínicamente a través del PASI la extensión y severidad de la enfermedad la eficacia clínica global y la tolerancia de la medicación. Se realizaron estudios de laboratorio (hematología, función renal, hepática, calcio sérico y urinario, fósforo, PTH y 25 hidroxivitamina D, antes de iniciar el tratamiento y las cuatro semanas. Resultados: 14 niños completaron el estudio, 7 mujeres y 7 varones. La edad promedio fue de 9 años. El PASI diminuyó en el 71%. No se detectaron efectos adversos a excepción de un leve ardor en dos pacientes. No hubo alteraciones de los parámetros de laboratorio incluyendo aquellos relacionados con la homeostasis del calcio. La tolerancia de la medicación fue excelente. Conclusiones: El ungüento de calcipotriol es un tratamiento seguro y eficaz para la psoriasis infantil. Constituye una terapéutica aceptable y útil junto a otros tratamientos antipsoriáticos furante la infancia.