An innovative, simple, fast, and less toxic high-performance liquid chromatographic method for determination of prednisone in capsules

ABSTRACT Prednisone is an anti-inflammatory steroid drug widely used in clinical practice. However, no high-performance liquid chromatographic (HPLC) method has been described in the literature for the determination of prednisone in capsules until now. Thus, an HPLC method was developed using a C18 (250x4.0, 5 µm) column, with methanol:water (70:30) as mobile phase at a flow rate of 1 mL/min and detection at 240 nm. The developed method was validated following current Brazilian legislation. Additionally, linearity was assessed by evaluating the assumptions of normality, homoscedasticity, and independency of residuals, and the fit to the linear model. The method showed linearity (r2>0.99) over the range of 14.0-26.0 µg/mL, selectivity, precision (RSD<2.0%), robustness, and accuracy (average recovery of 100.05%). The chromatographic procedure was applied for assay and uniformity content determination of three different batches of prednisone capsules, showing to be suitable for their quality control.

Fitofotodermatite por Ruta graveolens com manifestação cutânea extensa / Phytophotodermatitis due to Ruta graveolens with extensive cutaneous manifestation

Dermatite de contato por planta ou fitodermatite é uma erupção cutânea resultante do contato com substâncias produzidas por diferentes espécies de vegetais. Ruta graveolens, popularmente conhecida como arruda, é uma planta da família das Rutaceae, que inclui algumas frutas cítricas, e contém inúmeras substâncias químicas fotossensíveis, incluindo os furocumarínicos. Relatamos um caso de reação de fitofototoxicidade grave em uma paciente que usou uma infusão de arruda pelas supostas qualidades ”místicas e purificadoras” da planta com extensa erupção cutânea.

Plant dermatitis or phytodermatitis is a cutaneous eruption resulting from contact with substances produced by different plant species. Ruta graveolens, popular known as common rue, is an herbal plant from the Rutaceae family, which includes the citrus fruits, and contains numerous photosensitizing substances, including furocoumarins. We report a severe case of phytophototoxicity reaction in a patient who used a common rue infusion because of its “powerful and purification” qualities.

Infusão contínua de morfina ou fentanil, associados à lidocaína e cetamina, em cães anestesiados com isofluorano / Continuous infusion of morphine or fentanyl, associated to lidocaine and ketamine, in isofluorane-anesthetized dogs

A técnica de analgesia multimodal, por meio da infusão contínua de fármacos, pode ser empregada para diminuir a incidência de sensibilização central durante a anestesia. Avaliaram-se as características cardiorrespiratórias, durante o procedimento de artroscopia de joelho, em cães anestesiados com isofluorano e monitorados por meio do índice biespectral, submetidos à infusão contínua de morfina ou fentanil, associada à lidocaína e cetamina. Utilizaram-se 16 cães adultos, machos ou fêmeas, os quais foram distribuídos aleatoriamente em dois grupos, denominados MLK - que recebeu morfina (3,3μg/kg/min), lidocaína (50μg/kg/min) e cetamina (10μg/kg/min) ou FLK - em que foi substituída a morfina pelo fentanil (0,03μg/kg/min). Os cães foram pré-tratados com levomepromazina (0,5mg/kg IV), induzidos à anestesia com propofol (5mg/kg) e mantidos com isofluorano, ajustando-se a concentração para obterem-se valores de índice biespectral entre 55 e 65. As mensurações da frequência cardíaca (FC), dos parâmetros eletrocardiográficos (ECG), das pressões arteriais sistólica (PAS), diastólica (PAD) e média (PAM), da tensão de dióxido de carbono expirado (EtCO2), da saturação de oxi-hemoglobina (SpO2), da frequência respiratória (FR) e da temperatura esofágica (T) iniciaram-se 30 minutos após a indução (M0) e continuaram após o início da infusão das soluções, em intervalos de 15 minutos (M15 a M75). Diferenças entre os grupos foram registradas para duração do complexo QRS (M60), para FC e T, entre M30 e M75, com MLK apresentando médias maiores que FLK, que registrou médias maiores que MLK para a SpO2 (M60), para os intervalos QT (M30 e M75) e RR (M0, M60 e M75). Concluiu-se que o emprego de morfina ou fentanil, associados à lidocaína e cetamina, promove efeitos semelhantes e não compromete as características avaliadas.

The multimodal analgesia technique by continuous infusion of drugs can be used to decrease central sensitization during anesthesia. Cardiorespiratory parameters in isofluorane-anesthetized dogs during joint arthroscopy were evaluated. For this, 16 adult mongrel dogs were randomly divided into two groups, named MLK (morphine (3.3mg/kg/min), lidocaine (50μg/kg/min) and ketamine (10mg/kg/min)) or FLK (replacing morphine by fentanyl (0.03mg/kg/min). Levomepromazine (0.5mg/kg IV) was used as a preanesthetic medication, and propofol (5mg/kg IV) was used for induction and isoflurane was used for maintained general anesthesia, allowing the bispectral index to be maintained between 55 and 65. The measurements of heart rate (HR), eletrocardiographic, systolic (SAP), diastolic (DAP) and mean (MAP) arterial pressures, end-tidal carbon dioxide partial pressure (ETCO2), pulse oxygen saturation (SpO2) respiratory rate (RR) and esophageal temperature (T) were performed 30 minutes after induction (M0), and after the infusion of solutions, at 15 minute intervals (M15 to M75). Differences between groups were registered for the duration of the QRS complex (M60), for HR and T (from M30 to M75), with MLK recording a higher mean than FLK, which registered a lower value than MLK for SpO2 (M60), QT (M30 and M75) and RR (M0, M60 and M75) intervals. It was concluded that morphine or fentanyl, associated with lidocaine and ketamine, promotes similar effects and does not impair the parameters evaluated.

Tratamento clínico das reações da Hanseníase com repercussão neurológica – revisão histórica / Clinical treatment of leprosy reactions affecting nerves - historical review

Foi realizada uma busca na literatura sobre o tratamento da neuropatia da hanseníase durante episódios reacionais, no tocante às reações tipo 1 e tipo 2. O levantamento refere-se ao período 1976-2010. Foram consultadas as bases de dados LILAU, MEDLINE e LILACS. O enfoque principal foi o tratamento das reações hansênicas, com esteróides via oral empregado nos Programas de Controle da Hanseníase.

An extensive search on the treatment of leprosy reactions in nerves is presented. It covers almost four decades, from 1976 to 2010. The data bases screened were the LILAU, MEDLINE and LILACS. The focal point was to review the steroid treatment indication in the Leprosy Control Programs.

Effects of triptolide on hypothalamic-pituitary-adrenal axis of rats / 法医学杂志

OBJECTIVE@#To observe the effects of triptolide on the hypothalamic-pituitary-adrenal axis (HPAA) of rats in light of morphological and functional changes.@*METHODS@#Thirty Sprague-Dawley (SD) male rats were randomized into 3 groups and given 2% propylene glycol, mixture of propylene glycol and prednisone acetate or compounds of propylene glycol and triptolide by gavage, respectively, for consecutive 7 weeks. Determination in the 3 groups was conducted concerning the contents of blood plasma cortisol (COR), adrenocorticotropic hormone (ACTH) and corticotropin-releasing hormone (CRH) besides measurement of the rats' body weight, coefficient of the adrenal gland and observation of the histopathological changes in fascicular zone of adrenal cortex. Immunohistochemical staining technique was used to detect the expression of ACTH in pituitary in the 3 groups.@*RESULTS@#(1) The content of COR in the groups of triptolide and prednisone acetate appeared lower and serum ACTH showed no significant difference, but CRH in the group of triptolide was augmented as compared with the control group (P < 0.05). (2) The rats' weight in the groups of triptolide and prednisone acetate was declined, and yet, the coefficient of the adrenal gland remained no significant change in comparison with the controls. HE staining and electron microscopy examination revealed thinned and constricted zona fasciculata in adrenal gland in the rats of triptolide and prednisone acetate, with hypofunction. ACTH expression in the group of triptolide was higher than that of the control group (P < 0.05).@*CONCLUSION@#Morphologically and functionally, the findings suggest that long-term use of triptolide may result in atrophied cortex and hypofunction of the adrenal gland, leading to augmented production and secretion of CRH and ACTH from respective hypothalamic and pituitary.

Short-term Efficacy of Topical Immunosuppressive Agents on the Survival of Cultivated Allo-Conjunctival Equivalents

PURPOSE: To investigate the short-term efficacy of topical immunosuppressive agents on the survival of cultivated allo-conjunctival equivalents. METHODS: Twenty-five eyes of New Zealand white rabbits were included. Temporal conjunctivae were trephined to a diameter of 7.5 mm, and then cultured allo-conjunctival epithelial cells on amniotic membrane were transplanted onto them. Various immunosuppressants including steroid, cyclosporine, and rapamycin were applied topically four times a day for a week. Epithelial defects and graft edema were graded daily. Numbers of inflammatory cells were measured in H&E. PKH26 and cytokeratin 4 and 7 were immunostained. RESULTS: Earlier epithelialization was observed in 1% steroid-treated eyes and defects persisted significantly in 0.5% CsA applied eyes. In histology, PKH26 positive cells considered as donor cells were only found in 1% steroid or 0.01% rapamycin applied eyes. 1% steroid- or 0.01% rapamycin-applied eyes both showed positive staining for keratin-4 and -7. Inflammatory cells were less found in 1% steroid or 0.01% rapamycin treated eyes. CONCLUSIONS: Topical steroid or rapamycin can help to suppress acute inflammation and enhance the acute survival of transplanted conjunctival cells.

Comportamiento clínico del síndrome nefrotico corticoresistente en niños atendidos en el servicio de nefrología, Hospital Manuel de Jesús Rivera, en el período 2000-2004 / Clinical behavior of the syndrome nefrotico corticoresistente in children assisted in the nefrología service, Hospital Manuel of Jesus Rivera, in the period 2000-2004

Se presente un estudio descriptivo de corte transversal en todos los niños atendidos en el servicio de nefrología del Hospital Manuel de Jesús Rivera con diagnóstico de Síndrome Nefrótico Corticorresistente, en el período 2000-2004. El universo estuvo conformado por 48 pacientes, con dicho diagnóstico, la muestra es igual al universo, ya que cumplieron con los criterios de inclusión, que corresponde al 18.3 porciento del total de síndrome nefrótico. Se encontraron los siguientes resultados: El etáreo que con mas frecuencia se diagnóstico síndrome nefrótico corticoresistente fue el comprendido entre los 3 a 6 años predominando en el sexo femenino del área urbana y eutróficos. Las manifestaciones clínicas más frecuentes fueron proteinuria y edema. Se realizó biopsia renal percutánea a 21 pacientes, la lesión histológica que prevaleción fue la Glomeruloesclerosis. La totalidad de los pacientes en estudio, recibieron tratamiento con Prednisona. La mayoría de los pacientes fue egresado vivo y un 56 porciento ha evolucionado hacia insufiencia Renal Crónica, necesitando diálisis peritoneal un 12.5 porciento. Se puede concluir que el Síndrome Nefrótico es una de las patologías que con mayor frecuencia ingresa al servicio de Nefrología. Siendo el corticorresistente el más difícil de manejar y que con mayor frecuencia evoluciona hacia insuficiencia Renal Crónica...

comparative efficacy of oral prednisone with intramuscular triamcinolone in acute exacerbation of asthma

Corticosteroids are recommended for emergency management of an asthmatic attack. This study was designed to compare the effectiveness of oral and intramuscular steroid on spirometric results in acute asthma. We performed a randomized trial involving 88 adults, aged 15-70 years, with acute exacerbation of asthma requiring treatment with steroids. All had been treated with standard bronchodilator regimens and then received oral prednisone, 40 mg/day for 7 days, or 40 mg/day intramuscular triamcinolone long acting [LA] for 3 days. Spirometric variable and percentage of change to baseline forced vital capacity [FVC] and forced expiratory volume in 1 second [FEV1] after treatment were calculated. Baseline characteristic were comparable in the oral prednisone group [n=44] and in the intramuscular triamcinolone LA groups [n=44]. After 7 days of treatment, the mean [SD] FEV1 and FVC in both groups improved statistically over baseline values [P<0.001]. The median percentage change improvement of FEV1 between two treatment groups was statistically significant: 68 +/- 45.3% vs. 53.4 +/- 46.5%, P=0.04] respectively, but for FVC although improvement with prednisone was better than intramuscular triamcinolone LA groups, it was not statistically significant [52.6 +/- 40.1% vs. 45.8 +/- 39.9%, P=0.43] respectively. We conclude that in adults with acute asthma, oral prednisone is more effective than intramuscular triamcinolone LA in improvement of FEV1, but although efficacy of oral prednisone in improvement of FVC is more than intramuscular triamcinolone LA group, this effect is not significant

Introducción de micofenolato asociado a suspensión o reducción de la ciclosporina en trasplante renal: evaluación de una estrategia para el manejo de la nefropatía crónica del injerto / Effects of the administration of micofenolate mofetil associated to suspension or reduction of the cyclosporin in kidney transplant: evaluation of a management strategy of the chronic graft nephropathy

Esta revisión incluyó seis pacientes trasplantados, en tratamiento con CyA (Neoral) y Prednisona, con diagnóstico clínico de NCI caracterizado por un alza progresiva de la creatinina plasmática, y en cuatro de ellos estudio histológico concordante. MM se incorporó en un lapso no inferior a seis semanas, período en el cual se redujo y/o suspendió la CyA. La función renal y las complicaciones del tratamiento se evaluaron semanalmente en este período y en forma mensual hasta los 24 meses. La introducción de MM se efectuó en promedio a los 66 meses post-trasplante (rango 12 a 240 meses). Durante los 24 meses de seguimiento, se observó una tendencia progresiva a disminuir los niveles de creatinina. Sin embargo, esta diferencia no fue estadísticamente significativa. Durante este período no se observó ningún episodio de rechazo agudo o eventos adversos mayores. Sólo un paciente presentó toxicidad gastrointestinal, secundaria al uso de MM. La adición de MM acompañado de reducción o suspensión de CyA, en este grupo de pacientes con NCI, permitió mantener estables los niveles de creatinina durante el período en estudio, disminuyendo aparentemente la progresión de la enfermedad. La conversión demostró ser segura.

Neumonía intersticial no específica / Diffuse idiopathic interstitial lung disease

Se presenta un paciente, clínicamente calificado como broncoquiolitis obliterante con neumonía demostró una neumonía intersticial inespecífica, entidad poco frecuente, recientemente descrita, cuyo reconocimiento es importante por responder a tratamiento corticoidal, al contrario de la fibrosis intersticial usual, afección más frecuente con la cual ha sido confundida bajo la categoría clínica de fibrosis pulmonar idiopática

Hepatitis inmune temprana en el curso del síndrome de Sjögren en pediatría / Early immune hepatitis in the course of the Sjögren's syndrome in children

La hepatitis inmune corresponde a una enfermedad necroinflamatoria del hígado, de causa desconocida, asociada a la presencia de autoanticuerpos circulantes. Puede presentarse aisladamente, o en asociación a otras enfermedades autoinmunes. Entre estas, destaca el síndrome de Sjögren, que compromete preferentemente a las glándulas salivales, aunque puede afectar a cualquier segmento del tubo digestivo, especialmente el hígado. Reportamos el caso de una niña de 12 años de edad, portadora de Síndrome de Sjögren, quien durante la evolución de su enfermedad presentó alteración de transaminasas, fosfatasas alcalinas y bilirrubina. El estudio etiológico descartó infección por virus hepatótropos y enfermedades metabólicas. Se detectó IgM e IgG a Virus de Epstein-Barr, anticuerpos antinucleares, anticuerpos anti-Ro y anti-La, y anticuerpos antimúsculo liso positivos. El estudio histológico de la paciente confirmó la presencia de una hepatitis crónica activa, quien luego de 2 años de terapia esteroidal, presentó mejoría de exámenes hepáticos con persistencia de la lesión histológica

Mejoría en el pronóstico de la leucemia linfoblástica aguda en niños de un país en desarrollo: resultados del protocolo nacional chileno PINDA 87 / Improved outcome for acute lymphoblastic leukemia in children of a developing country: results of the chilean national trial PINDA 87

Un grupo oncológico pediátrico nacional, PINDA, reporta el primer protocolo prospectivo, no randomizado, para tratamiento de la leucemia linfoblástica (LLA), usando una versión modificada del protocolo de Berlín-Frankfurt-Munster (LLA BFM 86). Los objetivos de este estudio fueron clasificar inmunofenotipos, disminuir radioterapia de cráneo y comprobar si este protocolo podía mejorar la sobrevida de nuestros pacientes. Procedimiento: desde junio 1987 a junio 1992 se registraron 444 pacientes, no seleccionados; de ellos 425 fueron evaluables. La terapia fue estratificada según riesgo: riesgo bajo (RB), riesgo alto (RA) y riesgo muy alto (RMA). Los pacientes en RB y RA recibieron inducción con protocolo I, consolidación con protocolo M (RMA usó protocolo E), reinducción con protocolo II y mantención. Todos recibieron tratamiento de prefase con prednisona oral y metotrexato (MTX) intratecal. Radioterapia de cráneo solo en RA y RMA (12-18 Gy). Los siguientes cambios se introdujeron al protocolo LLA BFM 86: en protocolo M 1 g/m² en vez de 5 g/m²; en protocolo E, 1 g/m² de citarabina en vez de 2 g/m², la mitoxantrona e ifosfamida fueron sustituidas por teniposido y ciclofosfamida. Resultados: inmunofenotipo: LLA común 67,4 por ciento, LLA proB 14 por ciento, LLA T 10 por ciento, LLA preB 4,3 por ciento. La frecuencia de sobrevida libre de eventos (SLE) global a 5 años fue 60 por ciento ñ 2 por ciento error standard; según riesgo fue: RB 75 por ciento, RA 62 por ciento, RMA 28 por ciento con una mediana de seguimiento de 6,5 años (rango 4,5 - 9,5 años). La incidencia acumulada de recaída en sistema nervioso central SNC fue 5,4 por ciento. Conclusión: hemos tenido éxito en realizar un estudio a nivel nacional. Nuestra estrategia para adaptar el protocolo BFM fue efectiva para mejorar la SLE. La distribución por fenotipos es similar a otras series

Tratamiento con dosis bajas de ciclosporina A en pacientes con enfermedad ocular inflamatoria de etiología no infecciosa / Treatment of non infectious ocular inflammatory disease with low doses of cyclosporin A

Background: Cyclosporin A has an adequate immunosuppressive capacity and can be useful in the treatment of non infectious ocular inflammatory diseases. Aim: To describe the clinical effect of cyclosporin A treatment in low doses, along with corticosteroids, in the treatment of refractory ocular inflammatory diseases. Patients and methods: Twenty patients (13 female), aged 17 to 74 years old with severe and refractory ocular inflammatory diseases were studied. All except one, received variable doses of prednisone (10 to 60 mg/kg/day) and all received cyclosporin in doses that started in 2.5 mg/day and were increased to 5 mg/kg/day, according to clinical response. Patients were followed from 8 to 24 months, with monthly assessments of ocular inflammation (using a four point score), visual acuity and adverse effects of treatment. Results: A two points or more reduction in the ocular inflammation score was observed in 52 percent of patients. Visual acuity improved in 10 subjects, stabilized in 8 and worsened in 2. Prednisone doses were reduced in most patients. Observed adverse effects were hypertension in 2 patients, creatinine elevation in 2, gastrointestinal disturbances in 3 and hypertrichosis in 12. A reduction of cyclosporin dose was required in these cases, but it was discontinued only in one patient with a vascular purpura. Conclusions: Low cyclosporin doses, associated to prednisone, are useful to reduce inflammation and improve visual acuity in patients with non infectious ocular inflammatory diseases, refractory to other treatment methods

Púrpura trombocitopénica idiopática aguda en niños: un estudio prospectivo de tratamiento con y sin prednisona / Acute idiopathic thrombocytopenic purpura in children: a prospective study comparing treatment with or without prednisone

Se estudian prospectivamente 52 pacientes con púrpura trombocitopénica idiopática (PTI), cuyas edades fluctuaron entre un mes y 19 años, para evaluar la respuesta al tratamiento randomizado con y sin prednisona (PDN). 27 pacientes recibieron PDN en dosis mg/kg/día durante un mes (grupo I), y los que normalizaron el recuento plaquetario, lo hicieron en una mediana de 33 días. 25 pacientes fueron el grupo control (grupo 2), sin tratamiento, y los que normalizaron sus plaquetas, lo hicieron en una mediana de 30 días. 22 pacientes, en número equivalente de cada uno de los grupos, no recuperaron sus plaquetas en el período de 6 meses, transformándose la enfermedad en una PTI crónica. Se concluye que la normalización del recuento plaquetario es independiente del valor inicial y del uso o no uso de PDN, no modificando este medicamento la evolución natural de la enfermedad. finalmente la evolución de estos pacientes orienta a que el reposo es una medida terapéutica importante para evitar los riesgos de hemorragias

Effect of methyl-prednisone and cyclosporine on the lipid pattern and polyunsaturated fatty acid biosynthesis in the rat

The hyperlipidemia posttransplant has been largely attributed to immunosuppressant agents. In the present work we evaluated the effect of oral administration of cyclosporine (5 mg/kg/day) and/or methyl1-prednisone (1 mg/kg/day) on lipid composition and polyunsaturated fatty acid biosynthesis in normal adult male rats. The results obtained showed that both agents produced a delay on the growth together with a significant loss of body weight. In liver microssomal fraction from rats treated with methyl1-prednisone, a depression in delta 6 and delta 5 desaturation activited, was observed. This effect was corroborated in the fatty acid pattern through the enhancement of linoleic and dihomo-gamma-linolenic acids, and a depression of arachidonic acid. Similar results were noticed in those rats treated with both drugs when compared to the controls. No changes were observed either in the amount of liver microsomal total lipids or in the fatty acid composition of kidney and testis microsomes, as well as in erythrocyte membranes, among the different groups studied. Cyclosporine alone produced a significant depression in plasma triglycerides and showed no modifications in the other lipid parameters studied compared to the controls. Fluorescence anisotropy measured in the different membranes was not modified by the several treatments used. In view of the aforementioned data, in can be stated that methyl-prednisone would be the responsible for many of the lipid disorders that can be observed in posttransplant patients when they are subjected to the combined immunotherapy with cyclosporine.

Análisis de sobrevida a 5 años de trasplante renal con donante cadáver: influencia de histocompatibilidad HLA en 100 casos / Analysis of 5 year survival of renal transplant with cadaver donor: influence of HLA histocompatibility in 100 cases

Se estudian los resultados globales de sobrevida de paciente e injerto a 5 años plazo y la influencia de la histocompatibilidad HLA en una serie de 100 trasplantes renales primarios donante cadáver. El tratamiento inmunosupresor fue Ciclosporina A, Azatioprina y Prednisona. La sobrevida actuarial a 1 y 54 años de pacientes e injerto fue del 96-91 por ciento y 71-70 por ciento respectivamente. Si bien se observó una tendencia a mejores sobrevidas para mejores compatibilidades HLA-DR, HLA B-DR y HLA A-B y DR, estos resultados no tienen significación estadística

Síndrome de Vogt Koyanagi Harada e Esclerite / Vogt Koyanagi Harada Syndrome and Scleritis

Apresentaçäo de uma rara associaçäo de Vogt Koyanagi Harada com esclerite anterior difusa näo necrosante. Ao contrário da pan-uveíte granulomatosa bilateral que respondeu favoravelmente aos corticosteróides associados ao clorambucil, a severa inflamaçäo escleral só se mostrou sensível à ciclosporina

Influência da ciclosporina e da prednisona na fase aguda da infecçäo experimental de camundongos pelo trypanosoma cruzi / Effect of cyclosporin and prednisone on the acute phase of experimental infection of mice by trypanosoma cruzi

As relaçöes entre infecçäo pelo Trypanosoma cruzi, humana ou experimental, e imunodepressäo têm maior interesse ultimamente, sobretudo em virtude do maisamplo uso de fármacos que influem na imunidade e dos programas de transplantes de órgäos hoje em nítida expansäo. Com o advento da ciclosporina, tornou-se necessário conhecer adequadamente a participaçäo dela quando presente a parasitose devida ao T. cruzi e, por isso, foi efetuado o presente estudo, referente `a fase aguda, em camundongos, sucedendo comparaçäo com a atividade da prednisona. Ficou verificado que a ciclosporina, isoladamente ou associada ao corticóide promove maiores acentuaçöes parasitárias, avaliadas através de parasitemia, quantidades de formas amastigotas no coraçäo e intensidade do processo inflamatório nesse orgäo. Tais conhecimentos poderäo ser úteis em trabalhos assistenciais, especialmente no sentido de suscitar atençäo, controle estrito e eventual ajuda de antiparasitários.

Estudo comparativo sobre a influência do corticosteróide deflazacort (DL458) e prednisona na tolerância a glicose e a secreçäo de insulina em mulheres normais / A comparative study on the influence of the corticosteroid deflazacort (DL-458) and prednisone in the glucose tolerance and insulin secretion in healthy women

Foram avaliadas comparativamente as influências do deflazacort e da prednisona sobre a tolerância a glicose e a secreçäo de insulina em 10 mulheres sadias. As voluntárias foram submetidfas ao teste de tolerância a glicose (GTT) em três etapas, sendo as glicemias dosadas pelo método da glicose-oxidase e as insulinemias pelo teste de radioimunoensaio. Os resultados obtidos demonstram menor açäo diabetogênica do deflazacort comparado com a prednisona