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Journal of Forensic Medicine ; (6): 428-430, 2007.
Artigo em Chinês | WPRIM | ID: wpr-983332

RESUMO

OBJECTIVE@#To study the role of dopamine D3 receptor involved in the amphetamine-induced conditioned place preference (CPP) in mice.@*METHODS@#The CPP was observed in D3 receptor knock-out (D3RKO) mice and C57BL/6 wild-type control mice after administration of amphetamine. The data were analyzed with a two-way ANOVA using the SPSS 13.0 software.@*RESULTS@#D3RKO mice showed a significant amphetamine-induced CPP (P<0.001), compared with the ones administered with saline in C57BL/6 control mice.@*CONCLUSION@#The results indicate that amphetamine can produce significant CPP in dopamine D3 receptor knock-out mice, suggesting that amphetamine-induced addiction can be inhibited by dopamine D3 receptor.


Assuntos
Animais , Feminino , Masculino , Camundongos , Anfetamina/farmacologia , Comportamento Animal/efeitos dos fármacos , Condicionamento Operante/efeitos dos fármacos , Modelos Animais de Doenças , Técnicas de Inativação de Genes , Camundongos Endogâmicos C57BL , Camundongos Knockout , Atividade Motora/efeitos dos fármacos , Tempo de Reação , Receptores de Dopamina D3/fisiologia
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