Effect of gold thiomalate on cell proliferation and collagen synthesis of synovial cells in culture.

Human synovial cells from cases of rheumatoid and osteoarthritis were cultured and at their 3-5 passages, were treated with gold thiomalate. At early-log phase gold thiomalate arrested the proliferation of cells. However, at confluent state shere was a slight proliferation of synovial cells. This was followed by an increase in prolyl hydroxylase, collagen and protein synthesis, indicating that gold salts directly stimulate the synovial cells.

Doença reumatóida: avaliaçäo da terapêutica áurica em 30 pacientes / Rheumatoid disease: therapeutic evaluation of 30 patients treated with gold salts

O emprego do aurotiomalato de sódio mostrou-se efetivo em 80% dos pacientes, com apreciável efeito córtico-economizador. Os paraefeitos ocorreram em percentagem insignificante. A terapia remissiva deve ser utilizada em estágios precoces da enfermidade, associada aos antiinflamatórios e medidas físico e psicoterápicas