Complicaciones letales y linfocitopenia CD3+Periférica pretratamiento en linfomas No Hodgkin. Reporte de 5 casos / Lethal complications and peripheral lymphocytopenia CD3+ pretreatment in Non-Hodgkin lymphoma. A report of five cases

Multiple immune impairments in Non-Hodgkin patients are associated with their clinical development. The aim of this study was to describe the composition of peripheral T cell subpopulations before treatment in patients who died from infection or serious radiogenic complication together with tumoral activity. During a follow-up period of 8.18 years as an average; 5 cases affected by any of these complications which were not controlled by the treated were recorded. Lymphocytopenia CD3+ was the only common datum observed in the analysis covering variables of recognized prognostic death value. It was concluded that the low CD3+ count is a comorbid prognostic factor in Non-Hodgkin lymphoma that should not be ignored because of its fatal consequences

Suppression of the IgE antibody response by Ascaris suum components: effect of x-irradiation

The effect of X-irradiation on the supperession of IgE antibody responses induced by some of the Ascaris suum (ASC) components was analyzed in mice (7-week old A?Sn females). Treatment with 300 R 24h before immunization with 50 *g OVA and 200 *g ASC suppressive components abolished the damping effect on ati-OVA IgE antibody levels. The same effect was observed on the anti-ASC IgE antibody response obtained in mice injected with 200 *g ASC immunogenic plus 200 *g ASC suppressive components. Moreover, the failure of suppressive components to induce an IGE anti-ASC antibody response on their own was also abolished by X-irradiation. These results indicate that the suppressive components are able to elicit an IgE antibody response, but simultaneously activate a regulatory mechanism which suppressive both the homologous (anti-ASC) and heterologous (anti-OVA) antibody formation