Assuntos
Humanos , Doenças de von Willebrand/complicações , Doenças de von Willebrand/diagnóstico , Hemofilia A/diagnóstico , Contagem de Plaquetas , Transtornos Herdados da Coagulação Sanguínea/diagnóstico , Controle de Qualidade , Tempo de Protrombina/métodos , Transtornos da Coagulação Sanguínea/patologiaRESUMO
The study was carried out in the Department of Physiology, Isra University, Hyderabad. Seventy three cases of viperidae snake bite were studied to observe the pattern of coagulopathy. All had prolonged clotting time at the time of admission. Prothrombin time was increased in 56 cases, activated partial thromboplastin time was increased in 63 cases, bleeding time was normal in all cases. Platelet count was decreased in 28 cases and fibrinogen levels were decreased in 36 cases. Disseminated intravascular coagulation was found to be the predominant pattern of coagulopathy in viperidae snake bite cases
Assuntos
Humanos , Masculino , Feminino , Venenos de Serpentes/sangue , Venenos de Serpentes/efeitos adversos , Transtornos da Coagulação Sanguínea/sangue , Transtornos da Coagulação Sanguínea/induzido quimicamente , Transtornos da Coagulação Sanguínea/diagnóstico , Transtornos da Coagulação Sanguínea/mortalidade , Transtornos da Coagulação Sanguínea/patologia , Coagulação Intravascular Disseminada , Testes de Coagulação SanguíneaRESUMO
The effects of Cobra Venom [CV] on blood coagulation, platelets and fibrinolytic system were studied in rabbits after injecting repeated doses of 0.05 MLD of the Venom. Thrombocytopenia was the earliest change to appear. It was followed by rise in serum fibrinogen degradation products and prolongation of prothrombin time, [PT] activated partial thromboplastin time [APTT] and thrombin time [TT] indicating a progressive consumption coagulapathy and activation of fibrinolysis. Red blood cell morphology was unchanged during first three weeks; whereas fragmentation appeared after fourth week and it increased in severity with further envenomations i.e., when chronic disseminated intravascular clotting was established
Assuntos
Animais , Venenos de Serpentes/toxicidade , Transtornos da Coagulação Sanguínea/sangue , Transtornos da Coagulação Sanguínea/induzido quimicamente , Transtornos da Coagulação Sanguínea/diagnóstico , Transtornos da Coagulação Sanguínea/patologia , Testes de Coagulação Sanguínea , Coagulação Intravascular Disseminada , Plaquetas , FibrinóliseRESUMO
A case of widespread hematogenous metastases and Trousseau's syndrome is reported in a 40 year-old white housewife with gastric cancer, presenting subdural hematoma, ecchymoses, epistaxis, stomach and uterine bleeding. After undergoing hematoma drainage, she was unsuccessfully treated with platelets, red blood cells, plasma cryoprecipitate transfusions, and antibiotics. Necropsy disclosed gastric ring-signet adenocarcinoma invading the serous layer, with massive disseminated intravascular coagulation and systemic neoplastic embolism. Multiple old and recent hyaline (rich in fibrin and platelets) microthrombi, and tumor emboli were observed in the bone marrow, meninges, liver, lungs, kidneys, lymph nodes, adrenals, thyroid, heart, pancreas, and ovaries (Krukenberg tumor)