Novel Case Report: A Previously Reported, but Pathophysiologically Unexplained, Association Between Collagenous Colitis and Protein-Losing Enteropathy May Be Explained by an Undetected Link with Collagenous Duodenitis.
Dig Dis Sci
; 66(12): 4557-4564, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1064547
ABSTRACT
Collagenous colitis (CC) is associated with non-bloody, watery diarrhea, which is pathophysiologically reasonable because normal colonic absorption (or excretion) of water and electrolytes can be blocked by the abnormally thick collagen layer in CC. However, CC has also been associated with six previous cases of protein-losing enteropathy (PLE), with no pathophysiologic explanation. The colon does not normally absorb (or excrete) amino acids/proteins, which is primarily the function of the small bowel. Collagenous duodenitis (CD) has not been associated with PLE. This work reports a novel case of CD (and CC) associated with PLE; a pathophysiologically reasonable mechanism for CD causing PLE (by the thick collagen layer of CD blocking normal intestinal amino acid absorption); and a novel association of PLE with severe COVID-19 infection (attributed to relative immunosuppression from hypoproteinemia, hypoalbuminemia, hypogammaglobulinemia, and malnutrition from PLE).
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Enteropatías Perdedoras de Proteínas
/
Colitis Colagenosa
/
Duodenitis
/
Duodeno
/
COVID-19
/
Aminoácidos
/
Absorción Intestinal
/
Mucosa Intestinal
Tipo de estudio:
Reporte de caso
/
Estudios diagnósticos
/
Estudio pronóstico
Tópicos:
Covid persistente
Límite:
Anciano
/
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Dig Dis Sci
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
S10620-020-06804-3
Similares
MEDLINE
...
LILACS
LIS