SARS-CoV-2 spillover transmission due to recombination event.
Gene Rep
; 23: 101045, 2021 Jun.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1085555
ABSTRACT
In late 2019, a novel Coronavirus emerged in China. Perceiving the modulating factors of cross-species virus transmission is critical to elucidate the nature of virus emergence. Using bioinformatics tools, we analyzed the mapping of the SARS-CoV-2 genome, modeling of protein structure, and analyze the evolutionary origin of SARS-CoV-2, as well as potential recombination events. Phylogenetic tree analysis shows that SARS-CoV-2 has the closest evolutionary relationship with Bat-SL-CoV-2 (RaTG13) at the scale of the complete virus genome, and less similarity to Pangolin-CoV. However, the Receptor Binding Domain (RBD) of SARS-CoV-2 is almost identical to Pangolin-CoV at the aa level, suggesting that spillover transmission probably occurred directly from pangolins, but not bats. Further recombination analysis revealed the pathway for spillover transmission from Bat-SL-CoV-2 and Pangolin-CoV. Here, we provide evidence for recombination event between Bat-SL-CoV-2 and Pangolin-CoV that resulted in the emergence of SARS-CoV-2. Nevertheless, the role of mutations should be noted as another influencing factor in the continuing evolution and resurgence of novel SARS-CoV-2 variants.
Bat-SL-CoV-2, Bat SARS like Coronavirus 2; COVID-19, coronavirus disease 2019; CoV, coronavirus; MERS, Middle East Respiratory Syndrome; Mutation; Pandemic; Phylogenetics; RBD, receptor binding domain; Recombination; SARS, severe acute respiratory syndrome; SARS-CoV-2; Virulence; hACE2, human angiotensin-converting enzyme 2
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Tipo de estudio:
Ensayo controlado aleatorizado
Tópicos:
Variantes
Idioma:
Inglés
Revista:
Gene Rep
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
J.genrep.2021.101045
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