Very fast-progressive pulmonary opacities and high inflammatory factors levels are associated with decease of young Coronavirus Disease 2019 patients.
Medicine (Baltimore)
; 100(7): e24668, 2021 Feb 19.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1091183
ABSTRACT
ABSTRACT We aimed to retrospectively analyze the clinical and computed tomography (CT) characteristics of young adults with Coronavirus Disease 2019 (COVID-19) pneumonia who were critically ill and to identify the features associated with non-survival.Thirty-eight COVID-19 patients (20-45âyears old, 28 men) who had been admitted in the intensive care unit were included, including 18 non-survivors (group 1) and 20 survivors (group 2). Their clinical characteristics and initial and follow-up CT were compared between groups.In group 1, the days from illness onset to death were 21.1â±â10.3âdays; 7 patients had underlying comorbidities. At admission, group 1 exhibited higher serum ferritin and interleukin-6 (IL-6) levels (1142.6â±â242.4âmg/L and 33.8â±â18.6âmmol/L) compared with group 2 (728.3â±â150.9âmg/L and 15.2â±â6.9âmmol/L, Pâ<â.01). Group 1 exhibited more rapidly progressive opacities and consolidation in follow-up CT (16.7â±â3.1 scores, 15.7â±â3.1 segments) than group 2 (11.4â±â4.0 scores, 10.3â±â4.6 segments, Pâ<â.01). The oxygenation index was lower (87.6â±â19.2 vs 99.1â±â20.4âmm Hg) and the mechanical ventilation duration was longer (14.7â±â6.9 vs 9.7â±â3.7âdays) in group 1 compare with group 2 (Pâ<â.01).Compared with the survivors, the non-survivors showed higher serum ferritin and IL-6 levels, more rapidly progressive opacities in CT, lower oxygenation index, and longer mechanical ventilation durations. Special attention to ferritin/IL-6 levels and oxygenation index as well as early CT application and timely reexaminations are important to identify the individuals who may be at risk of becoming critically ill.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Neumonía Viral
/
Tomografía Computarizada por Rayos X
/
COVID-19
Tipo de estudio:
Estudio de cohorte
/
Estudios diagnósticos
/
Estudio experimental
/
Estudio observacional
/
Estudio pronóstico
Tópicos:
Covid persistente
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Medicine (Baltimore)
Año:
2021
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS