Blockers of the SARS-CoV-2 3a Channel Identified by Targeted Drug Repurposing.
Viruses
; 13(3)2021 03 23.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1154526
ABSTRACT
The etiological agent of the COVID-19 pandemic is SARS-CoV-2. As a member of the Coronaviridae, the enveloped pathogen has several membrane proteins, of which two, E and 3a, were suggested to function as ion channels. In an effort to increase our treatment options, alongside providing new research tools, we have sought to inhibit the 3a channel by targeted drug repurposing. To that end, using three bacteria-based assays, we screened a library of 2839 approved-for-human-use drugs and identified the following potential channel-blockers Capreomycin, Pentamidine, Spectinomycin, Kasugamycin, Plerixafor, Flumatinib, Litronesib, Darapladib, Floxuridine and Fludarabine. The stage is now set for examining the activity of these compounds in detailed electrophysiological studies and their impact on the whole virus with appropriate biosafety measures.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Proteínas del Envoltorio Viral
/
Reposicionamiento de Medicamentos
/
Proteínas Viroporinas
/
SARS-CoV-2
/
COVID-19
Tipo de estudio:
Estudio de etiologia
/
Estudio pronóstico
Tópicos:
Medicina tradicional
Límite:
Humanos
Idioma:
Inglés
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
V13030532
Similares
MEDLINE
...
LILACS
LIS