Cytokine storm intervention in the early stages of COVID-19 pneumonia.
Cytokine Growth Factor Rev
; 53: 38-42, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: covidwho-116329
ABSTRACT
Clinical intervention in patients with corona virus disease 2019 (COVID-19) has demonstrated a strong upregulation of cytokine production in patients who are critically ill with SARS-CoV2-induced pneumonia. In a retrospective study of 41 patients with COVID-19, most patients with SARS-CoV-2 infection developed mild symptoms, whereas some patients later developed aggravated disease symptoms, and eventually passed away because of multiple organ dysfunction syndrome (MODS), as a consequence of a severe cytokine storm. Guidelines for the diagnosis and treatment of SARS-CoV-2 infected pneumonia were first published January 30th, 2020; these guidelines recommended for the first time that cytokine monitoring should be applied in severely ill patients to reduce pneumonia related mortality. The cytokine storm observed in COVID-19 illness is also an important component of mortality in other viral diseases, including SARS, MERS and influenza. In view of the severe morbidity and mortality of COVID-19 pneumonia, we review the current understanding of treatment of human coronavirus infections from the perspective of a dysregulated cytokine and immune response.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Neumonía Viral
/
Citocinas
/
Infecciones por Coronavirus
/
Betacoronavirus
/
Síndrome de Liberación de Citoquinas
/
Insuficiencia Multiorgánica
Tipo de estudio:
Estudio experimental
/
Estudio observacional
/
Estudio pronóstico
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Cytokine Growth Factor Rev
Asunto de la revista:
Alergia e Inmunología
/
Bioquímica
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
J.cytogfr.2020.04.002
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