An Impaired Inflammatory and Innate Immune Response in COVID-19.
Mol Cells
; 44(6): 384-391, 2021 Jun 30.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1259762
ABSTRACT
The recent appearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people around the world and caused a global pandemic of coronavirus disease 2019 (COVID-19). It has been suggested that uncontrolled, exaggerated inflammation contributes to the adverse outcomes of COVID-19. In this review, we summarize our current understanding of the innate immune response elicited by SARS-CoV-2 infection and the hyperinflammation that contributes to disease severity and death. We also discuss the immunological determinants behind COVID-19 severity and propose a rationale for the underlying mechanisms.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Síndrome Respiratorio Agudo Grave
/
Interacciones Huésped-Patógeno
/
Síndrome de Liberación de Citoquinas
/
SARS-CoV-2
/
COVID-19
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Mol Cells
Asunto de la revista:
Biologia Molecular
Año:
2021
Tipo del documento:
Artículo
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