SARS-CoV-2 attenuates corticosteroid sensitivity by suppressing DUSP1 expression and activating p38 MAPK pathway.
Eur J Pharmacol
; 908: 174374, 2021 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1322083
ABSTRACT
The efficacy of corticosteroids and its use for the treatment of SARS-CoV-2 infections is controversial. In this study, using data sets of SARS-CoV-2 infected lung tissues and nasopharyngeal swabs, as well as in vitro experiments, we show that SARS-CoV-2 infection significantly downregulates DUSP1 expression. This downregulation of DUSP1 could be the mechanism regulating the enhanced activation of MAPK pathway as well as the reported steroid resistance in SARS-CoV-2 infection. Moreover, chloroquine, an off labeled COVID-19 drug is able to induce DUSP1 and attenuate MAPK pathway; and is expected to improve sensitivity to steroid treatment. However, further mechanistic studies are required to confirm this effect.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Cloroquina
/
Proteínas Quinasas p38 Activadas por Mitógenos
/
Fosfatasa 1 de Especificidad Dual
/
Tratamiento Farmacológico de COVID-19
/
Glucocorticoides
Tipo de estudio:
Estudio observacional
Límite:
Adulto
/
Anciano
/
Humanos
/
Middle aged
Idioma:
Inglés
Revista:
Eur J Pharmacol
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
J.ejphar.2021.174374
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