Spatiotemporal invasion dynamics of SARS-CoV-2 lineage B.1.1.7 emergence.
Science
; 373(6557): 889-895, 2021 08 20.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1322770
ABSTRACT
Understanding the causes and consequences of the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern is crucial to pandemic control yet difficult to achieve because they arise in the context of variable human behavior and immunity. We investigated the spatial invasion dynamics of lineage B.1.1.7 by jointly analyzing UK human mobility, virus genomes, and community-based polymerase chain reaction data. We identified a multistage spatial invasion process in which early B.1.1.7 growth rates were associated with mobility and asymmetric lineage export from a dominant source location, enhancing the effects of B.1.1.7's increased intrinsic transmissibility. We further explored how B.1.1.7 spread was shaped by nonpharmaceutical interventions and spatial variation in previous attack rates. Our findings show that careful accounting of the behavioral and epidemiological context within which variants of concern emerge is necessary to interpret correctly their observed relative growth rates.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
SARS-CoV-2
/
COVID-19
Tipo de estudio:
Estudio observacional
Tópicos:
Variantes
Límite:
Humanos
País/Región como asunto:
Europa
Idioma:
Inglés
Revista:
Science
Año:
2021
Tipo del documento:
Artículo
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