Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection.
Mol Cancer
; 19(1): 80, 2020 04 28.
Artículo
en Inglés
| MEDLINE | ID: covidwho-133383
ABSTRACT
Recent studies have reported that COVID-19 patients with lung cancer have a higher risk of severe events than patients without cancer. In this study, we investigated the gene expression of angiotensin I-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) with prognosis in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). Lung cancer patients in each age stage, subtype, and pathological stage are susceptible to SARS-CoV-2 infection, except for the primitive subtype of LUSC. LUAD patients are more susceptible to SARS-CoV-2 infection than LUSC patients. The findings are unanimous on tissue expression in gene and protein levels.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Neumonía Viral
/
Serina Endopeptidasas
/
Carcinoma de Células Escamosas
/
Infecciones por Coronavirus
/
Peptidil-Dipeptidasa A
/
Betacoronavirus
/
Adenocarcinoma del Pulmón
/
Neoplasias Pulmonares
Tipo de estudio:
Estudio pronóstico
Tópicos:
Covid persistente
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Mol Cancer
Asunto de la revista:
Neoplasmas
Año:
2020
Tipo del documento:
Artículo
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