Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates.
Science
; 373(6561): eabj0299, 2021 Sep 17.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1334532
ABSTRACT
Immune correlates of protection can be used as surrogate endpoints for vaccine efficacy. Here, nonhuman primates (NHPs) received either no vaccine or doses ranging from 0.3 to 100 µg of the mRNA-1273 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. mRNA-1273 vaccination elicited circulating and mucosal antibody responses in a dose-dependent manner. Viral replication was significantly reduced in bronchoalveolar lavages and nasal swabs after SARS-CoV-2 challenge in vaccinated animals and most strongly correlated with levels of antiS antibody and neutralizing activity. Lower antibody levels were needed for reduction of viral replication in the lower airway than in the upper airway. Passive transfer of mRNA-1273induced immunoglobulin G to naïve hamsters was sufficient to mediate protection. Thus, mRNA-1273 vaccineinduced humoral immune responses are a mechanistic correlate of protection against SARS-CoV-2 in NHPs.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Anticuerpos Neutralizantes
/
Inmunogenicidad Vacunal
/
Vacunas contra la COVID-19
/
SARS-CoV-2
/
COVID-19
/
Anticuerpos Antivirales
Tópicos:
Vacunas
Límite:
Animales
Idioma:
Inglés
Revista:
Science
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
Science.abj0299
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