Unravelling the broader complexity of IL-6 involvement in health and disease.
Cytokine
; 148: 155684, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1355591
ABSTRACT
The classification of interleukin-6 (IL-6) as a pro-inflammatory cytokine undervalues the biological impact of this cytokine in health and disease. With broad activities affecting the immune system, tissue homeostasis and metabolic processes, IL-6 displays complex biology. The significance of these involvements has become increasingly important in clinical settings where IL-6 is identified as a prominent target for therapy. Here, clinical experience with IL-6 antagonists emphasises the need to understand the context-dependent properties of IL-6 within an inflammatory environment and the anticipated or unexpected consequences of IL-6 blockade. In this review, we will describe the immunobiology of IL-6 and explore the gamut of IL-6 bioactivity affecting the clinical response to biological drugs targeting this cytokine pathway.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Salud
/
Enfermedad
/
Interleucina-6
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Cytokine
Asunto de la revista:
Alergia e Inmunología
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
J.cyto.2021.155684
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