The structure of a dimeric form of SARS-CoV-2 polymerase.
Commun Biol
; 4(1): 999, 2021 08 24.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1371605
ABSTRACT
The coronavirus SARS-CoV-2 uses an RNA-dependent RNA polymerase (RdRp) to replicate and transcribe its genome. Previous structures of the RdRp revealed a monomeric enzyme composed of the catalytic subunit nsp12, two copies of subunit nsp8, and one copy of subunit nsp7. Here we report an alternative, dimeric form of the enzyme and resolve its structure at 5.5 Å resolution. In this structure, the two RdRps contain only one copy of nsp8 each and dimerize via their nsp7 subunits to adopt an antiparallel arrangement. We speculate that the RdRp dimer facilitates template switching during production of sub-genomic RNAs.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
SARS-CoV-2
Límite:
Humanos
Idioma:
Inglés
Revista:
Commun Biol
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
S42003-021-02529-9
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