Efficacy and Safety of Qingfei Paidu Decoction for Treating COVID-19: A Systematic Review and Meta-Analysis.
Front Pharmacol
; 12: 688857, 2021.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1378197
ABSTRACT
Background:
Qingfei Paidu decoction (QFPD) has been widely used in treating COVID-19 in China. However, there is still a lack of comprehensive and systematic evidence to demonstrate the effectiveness and safety of QFPD. This study aims to evaluate the efficacy and safety of QFPD in patients with COVID-19.Methods:
We searched seven databases up to 5 March 2021. Two reviewers independently screened studies, extracted data of interest, and assessed risk of bias. The Cochrane risk of bias tool was used to assess the risk of bias of randomized controlled trials. The Newcastle-Ottawa scale was used to assess the risk of bias of cohort and non-randomized trials. The "Quality Assessment Tool for Before-After (Pre-Post) Studies With No Control Group" was adopted for controlled pre-post studies. We used the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) to assess the certainty of evidence. We carried out a random effect meta-analysis using RevMan 5.3. For outcomes that could not be meta-analyzed, we performed a descriptive analysis.Results:
We identified 16 studies with 11,237 patients, including one RCT, six non-randomized trials, two cohort studies, and seven pre-post studies. The certainty of evidence was low to very low because of the observational study design. QFPD combined with conventional treatment might decrease the time for nucleic acid conversion (MD = -4.78 days, 95% CI -5.79 to -3.77), shorten the length of hospital stay (MD = -7.95 days, 95% CI -14.66 to -1.24), shorten the duration of symptoms recovery of fever (MD = -1.51 days, 95% CI -1.92 to -1.09), cough (MD = -1.64 days, 95% CI -1.91 to -1.36) and chest CT (MD = -2.23 days, 95% CI -2.46 to -2.00), improve the overall traditional Chinese medicine symptom scores (MD = 41.58 scores, 95% CI 32.67 to 50.49), and change the laboratory indexes, such as WBC, AST, and CRP.Conclusion:
QFPD combined with conventional treatment might be effective for patients with COVID-19. No serious adverse reactions related to QFPD were observed. Further high-quality studies are still needed in the future.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Tipo de estudio:
Estudio de cohorte
/
Estudio experimental
/
Estudio observacional
/
Estudio pronóstico
/
Ensayo controlado aleatorizado
/
Revisiones
/
Revisión sistemática/Meta análisis
Tópicos:
Medicina tradicional
Idioma:
Inglés
Revista:
Front Pharmacol
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
Fphar.2021.688857
Similares
MEDLINE
...
LILACS
LIS