ceRNA analysis of SARS-CoV-2.
Arch Virol
; 166(1): 271-274, 2021 Jan.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1384460
ABSTRACT
Viral RNAs can perturb the miRNA regulatory network, competing with host RNAs as part of their infective process. An in silico competing endogenous RNA (ceRNA) analysis has been carried on SARS-CoV-2. The results suggest that, in humans, the decrease of microRNA activity caused by viral RNAs can lead to a perturbation of vesicle trafficking and the inflammatory response, in particular by enhancing KLF10 activity. The results suggest also that, during the study of the mechanics of viral infections, it could be of general interest to investigate the competition of viral RNA with cellular transcripts for shared microRNAs.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
ARN Mensajero
/
ARN Viral
/
Redes Reguladoras de Genes
/
SARS-CoV-2
Límite:
Humanos
Idioma:
Inglés
Revista:
Arch Virol
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
S00705-020-04856-4
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