The dominant strain of SARS-CoV-2 is a mosaicism.
Virus Res
; 305: 198553, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1386720
ABSTRACT
COVID-19 is seriously threatening human health all over the world. A comprehensive understanding of the genetic mechanisms driving the rapid evolution of its pathogen (SARS-CoV-2) is the key to controlling this pandemic. In this study, by comparing the entire genome sequences of SARS-CoV-2 isolates from Asia, Europe and America, and analyzing their phylogenetic histories, we found a lineage derived from a recombination event that likely occurred before March 2020. More importantly, the recombinant offspring has become the dominant strain responsible for more than one-third of the global cases in the pandemic. These results indicated that the recombination might have played a key role in the pandemic of the virus.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Genoma Viral
/
Evolución Molecular
/
Recombinación Homóloga
/
SARS-CoV-2
/
COVID-19
/
Mosaicismo
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Ensayo controlado aleatorizado
Límite:
Humanos
País/Región como asunto:
Asia
/
Europa
Idioma:
Inglés
Revista:
Virus Res
Asunto de la revista:
Virología
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
J.virusres.2021.198553
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