Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease.

Sun, Qi; Ye, Fei; Liang, Hao; Liu, Hongbo; Li, Chunmei; Lu, Roujian; Huang, Baoying; Zhao, Li; Tan, Wenjie; Lai, Luhua

Sun, Qi; Ye, Fei; Liang, Hao; Liu, Hongbo; Li, Chunmei; Lu, Roujian; Huang, Baoying; Zhao, Li; Tan, Wenjie; Lai, Luhua.

Sun Q; BNLMS, Peking-Tsinghua Center for Life Sciences at College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Ye F; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, China CDC, Beijing, China.
Liang H; BNLMS, Peking-Tsinghua Center for Life Sciences at College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Liu H; BNLMS, Peking-Tsinghua Center for Life Sciences at College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Li C; Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Lu R; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, China CDC, Beijing, China.
Huang B; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, China CDC, Beijing, China.
Zhao L; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, China CDC, Beijing, China.
Tan W; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, China CDC, Beijing, China. tanwj28@163.com.
Lai L; BNLMS, Peking-Tsinghua Center for Life Sciences at College of Chemistry and Molecular Engineering, Peking University, Beijing, China. lhlai@pku.edu.cn.

Signal Transduct Target Ther ; 6(1): 212, 2021 05 29.

Artículo en Inglés | MEDLINE | ID: covidwho-1387227

Asunto(s)

Tratamiento Farmacológico de COVID-19; Proteasas 3C de Coronavirus/antagonistas & inhibidores; Ácido Oleanólico/análogos & derivados; SARS-CoV-2/enzimología; Antivirales/química; COVID-19/enzimología; COVID-19/virología; Química Computacional; Proteasas 3C de Coronavirus/química; Reposicionamiento de Medicamentos; Humanos; Factor 2 Relacionado con NF-E2/agonistas; Factor 2 Relacionado con NF-E2/química; Ácido Oleanólico/química; Inhibidores de Proteasas/química; Inhibidores de Proteasas/uso terapéutico; SARS-CoV-2/patogenicidad; Replicación Viral/efectos de los fármacos

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Ácido Oleanólico / Proteasas 3C de Coronavirus / SARS-CoV-2 / Tratamiento Farmacológico de COVID-19 Tipo de estudio: Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: Signal Transduct Target Ther Año: 2021 Tipo del documento: Artículo País de afiliación: S41392-021-00628-X

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