Evolutionary and codon usage preference insights into spike glycoprotein of SARS-CoV-2.
Brief Bioinform
; 22(2): 1006-1022, 2021 03 22.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1387712
ABSTRACT
Interaction of SARS-CoV-2 spike glycoprotein with the ACE2 cell receptor is very crucial for virus attachment to human cells. Selected mutations in SARS-CoV-2 S-protein are reported to strengthen its binding affinity to mammalian ACE2. The N501T mutation in SARS-CoV-2-CTD furnishes better support to hotspot 353 in comparison with SARS-CoV and shows higher affinity for receptor binding. Recombination analysis exhibited higher recombination events in SARS-CoV-2 strains, irrespective of their geographical origin or hosts. Investigation further supports a common origin among SARS-CoV-2 and its predecessors, SARS-CoV and bat-SARS-like-CoV. The recombination events suggest a constant exchange of genetic material among the co-infecting viruses in possible reservoirs and human hosts before SARS-CoV-2 emerged. Furthermore, a comprehensive analysis of codon usage bias (CUB) in SARS-CoV-2 revealed significant CUB among the S-genes of different beta-coronaviruses governed majorly by natural selection and mutation pressure. Various indices of codon usage of S-genes helped in quantifying its adaptability in other animal hosts. These findings might help in identifying potential experimental animal models for investigating pathogenicity for drugs and vaccine development experiments.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Evolución Biológica
/
Glicoproteína de la Espiga del Coronavirus
/
Uso de Codones
/
SARS-CoV-2
Tópicos:
Vacunas
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Brief Bioinform
Asunto de la revista:
Biologia
/
Informática Médica
Año:
2021
Tipo del documento:
Artículo
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