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SARS-CoV-2 in the semen: Where does it come from?
Massarotti, Claudia; Garolla, Andrea; Maccarini, Elena; Scaruffi, Paola; Stigliani, Sara; Anserini, Paola; Foresta, Carlo.
  • Massarotti C; Physiopathology of Human Reproduction Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
  • Garolla A; Unit of Andrology and Reproductive Medicine, Department of Medicine, University of Padova, Padova, Italy.
  • Maccarini E; Physiopathology of Human Reproduction Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
  • Scaruffi P; Physiopathology of Human Reproduction Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
  • Stigliani S; Physiopathology of Human Reproduction Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
  • Anserini P; Physiopathology of Human Reproduction Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
  • Foresta C; Unit of Andrology and Reproductive Medicine, Department of Medicine, University of Padova, Padova, Italy.
Andrology ; 9(1): 39-41, 2021 01.
Artículo en Inglés | MEDLINE | ID: covidwho-1388168
Información semántica de SemMedBD (por NLM)
1. Tract LOCATION_OF Male genital infection
Sujeto
Tract
Predicado
LOCATION_OF
Objeto
Male genital infection
2. Seminal fluid specimen PART_OF Patients
Sujeto
Seminal fluid specimen
Predicado
PART_OF
Objeto
Patients
3. Male genital infection PROCESS_OF Plant seeds
Sujeto
Male genital infection
Predicado
PROCESS_OF
Objeto
Plant seeds
4. Male Genital Organs LOCATION_OF Severe Acute Respiratory Syndrome
Sujeto
Male Genital Organs
Predicado
LOCATION_OF
Objeto
Severe Acute Respiratory Syndrome
5. Inferior Colliculus LOCATION_OF angiotensin converting enzyme 2
Sujeto
Inferior Colliculus
Predicado
LOCATION_OF
Objeto
angiotensin converting enzyme 2
6. Inferior Colliculus LOCATION_OF TMPRSS2 gene|TMPRSS2
Sujeto
Inferior Colliculus
Predicado
LOCATION_OF
Objeto
TMPRSS2 gene|TMPRSS2
7. tubular cells PART_OF Kidney
Sujeto
tubular cells
Predicado
PART_OF
Objeto
Kidney
8. Adult Germline Stem Cells LOCATION_OF TMPRSS2 gene|TMPRSS2
Sujeto
Adult Germline Stem Cells
Predicado
LOCATION_OF
Objeto
TMPRSS2 gene|TMPRSS2
9. Adult Germline Stem Cells LOCATION_OF ACE2 gene|ACE2
Sujeto
Adult Germline Stem Cells
Predicado
LOCATION_OF
Objeto
ACE2 gene|ACE2
10. Severe Acute Respiratory Syndrome PROCESS_OF Patients
Sujeto
Severe Acute Respiratory Syndrome
Predicado
PROCESS_OF
Objeto
Patients
11. Tract LOCATION_OF Male genital infection
Sujeto
Tract
Predicado
LOCATION_OF
Objeto
Male genital infection
12. Seminal fluid specimen PART_OF Patients
Sujeto
Seminal fluid specimen
Predicado
PART_OF
Objeto
Patients
13. Male genital infection PROCESS_OF Plant seeds
Sujeto
Male genital infection
Predicado
PROCESS_OF
Objeto
Plant seeds
14. Male Genital Organs LOCATION_OF Severe Acute Respiratory Syndrome
Sujeto
Male Genital Organs
Predicado
LOCATION_OF
Objeto
Severe Acute Respiratory Syndrome
15. Inferior Colliculus LOCATION_OF angiotensin converting enzyme 2
Sujeto
Inferior Colliculus
Predicado
LOCATION_OF
Objeto
angiotensin converting enzyme 2
16. Inferior Colliculus LOCATION_OF TMPRSS2 gene|TMPRSS2
Sujeto
Inferior Colliculus
Predicado
LOCATION_OF
Objeto
TMPRSS2 gene|TMPRSS2
17. tubular cells PART_OF Kidney
Sujeto
tubular cells
Predicado
PART_OF
Objeto
Kidney
18. Adult Germline Stem Cells LOCATION_OF TMPRSS2 gene|TMPRSS2
Sujeto
Adult Germline Stem Cells
Predicado
LOCATION_OF
Objeto
TMPRSS2 gene|TMPRSS2
19. Adult Germline Stem Cells LOCATION_OF ACE2 gene|ACE2
Sujeto
Adult Germline Stem Cells
Predicado
LOCATION_OF
Objeto
ACE2 gene|ACE2
20. Severe Acute Respiratory Syndrome PROCESS_OF Patients
Sujeto
Severe Acute Respiratory Syndrome
Predicado
PROCESS_OF
Objeto
Patients
ABSTRACT

BACKGROUND:

The recent report of SARS-CoV-2 presence in semen samples of six patients, including two subjects who were recovering from the clinical disease, re-opened the discussion on possible male genital tract infection, virus shedding in semen, sexual transmission and safety of fertility treatments during the pandemic period.

OBJECTIVES:

To explore current data and hypothesis on the possible sites of SARS-CoV-2 infection in the male reproduction system. MATERIALS AND

METHODS:

We reviewed the current literature to describe a) the evidences on angiotensin-converting enzyme 2 (AC2E) and transmembrane serine protease 2 (TMPRSS2) expression in the testes, accessory glands (including prostate) and the urinary tract; b) other coronaviruses' (SARS and MERS) ability to infect these sites.

RESULTS:

The co-expression of both ACE2 and TMPRSS2 genes was reported in spermatogonial stem cells, elongated spermatids, in at least a small percentage of prostate hillock cells and in renal tubular cells. Testicular damage was described in autopsies of SARS patients, without evidence of the virus in the specimens. Prostate is a known infection site for MERS-CoV. SARS-CoV-2 was detected in urines.

DISCUSSION:

There are still al lot of open questions on the effects of SARS-CoV-2 infection on the male reproductive tract. The presence of receptors is not a proof that the testis provides a site for viral infection and it is still unknown if SARS-CoV-2 is capable to pass the blood-testis barrier. The possibility of a prostate involvement has not been investigated yet we have no data, but theoretically it cannot be excluded. Moreover, the RNA detected in semen could have been just a residual of urinary shedding.

CONCLUSION:

Opening our prospective beyond the testis could be the key to better understand the possibility of a semen-related viral transmission as well as COVID19 short and long-term effects on male reproductive function.
Asunto(s)
Palabras clave

Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Semen / Testículo / SARS-CoV-2 / COVID-19 Tipo de estudio: Estudio diagnóstico Tópicos: Covid persistente Límite: Humanos / Masculino Idioma: Inglés Revista: Andrology Año: 2021 Tipo del documento: Artículo País de afiliación: ANDR.12839

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Semen / Testículo / SARS-CoV-2 / COVID-19 Tipo de estudio: Estudio diagnóstico Tópicos: Covid persistente Límite: Humanos / Masculino Idioma: Inglés Revista: Andrology Año: 2021 Tipo del documento: Artículo País de afiliación: ANDR.12839