Acute eosinophilic pneumonia: a fatal reaction to ado-trastuzumab.
BMJ Case Rep
; 14(9)2021 Sep 03.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1394072
ABSTRACT
Ado-trastuzumab emtansine (T-DM1) is a monoclonal antibody drug conjugate approved for the treatment of HER2-positive breast cancers. Presented here is a case report of a patient who developed fatal pulmonary toxicity in the form of acute eosinophilic pneumonia while undergoing treatment with T-DM1. Prior to beginning T-DM1 therapy, this patient had been treated with two HER2-targeted agents (trastuzumab, pertuzumab) per National Comprehensive Cancer Network (NCCN) guidelines. This case represents a novel presentation of toxicity associated with T-DM1 while perhaps demonstrating additive toxicity associated with multiple lines of HER2 targeted therapies.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Eosinofilia Pulmonar
/
Neoplasias de la Mama
/
Maitansina
Tipo de estudio:
Reporte de caso
/
Estudios diagnósticos
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
Bcr-2021-243881
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