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Clinical features of COVID-19 in Ghana: symptomatology, illness severity and comorbid non-communicable diseases.
Oduro-Mensah, Ebenezer; Tetteh, John; Adomako, Isaac; Adjei-Mensah, Evelyn; Owoo, Christian; Yawson, Anita O; Oliver-Commey, Joseph A; Puplampu, Peter; Samba, Ali; Yawson, Alfred E; Lartey, Margaret.
  • Oduro-Mensah E; National COVID-19 Treatment Centre, Ga East Municipal Hospital, Ghana Health Service (GHS).
  • Tetteh J; National COVID-19 Case Management Team, Ministry of Health, Accra, Ghana.
  • Adomako I; Department of Community Health, University of Ghana Medical School, College of Health Sciences, University of Ghana, Accra, Ghana.
  • Adjei-Mensah E; Department of Community Health, University of Ghana Medical School, College of Health Sciences, University of Ghana, Accra, Ghana.
  • Owoo C; Department of Community Health, University of Ghana Medical School, College of Health Sciences, University of Ghana, Accra, Ghana.
  • Yawson AO; National COVID-19 Treatment Centre, Ga East Municipal Hospital, Ghana Health Service (GHS).
  • Oliver-Commey JA; National COVID-19 Case Management Team, Ministry of Health, Accra, Ghana.
  • Puplampu P; National COVID-19 Treatment Centre, University of Ghana Medical Centre, Accra, Ghana.
  • Samba A; Department of Anaesthesia, University of Ghana Medical School, College of Health Sciences, University of Ghana, Accra, Ghana.
  • Yawson AE; National COVID-19 Treatment Centre, Ga East Municipal Hospital, Ghana Health Service (GHS).
  • Lartey M; Department of Anaesthesia, Korle-Bu Teaching Hospital, Accra, Ghana.
Ghana Med J ; 54(4 Suppl): 23-32, 2020 Dec.
Artículo en Inglés | MEDLINE | ID: covidwho-1436191
ABSTRACT

OBJECTIVE:

This analysis described the clinical features of COVID-19 in the early phase of the pandemic in Ghana.

METHODS:

Data were extracted from two national COVID-19 treatment centers in Ghana for over 11 weeks(from March to May 2020). Descriptive and inferential statistics were performed. Modified Ordered Logistic and Negative Binomial Regression analysis were applied to establish factors associated with illness severity and Non-communicable Disease (NCDs) counts respectively. All analysis was conducted at the 95% confidence level (p-value ≤ 0.05) using Stata 16.

RESULTS:

Among the 275 patients, the average age was 40.7±16.4, with a preponderance of males (54.5%). The three commonest symptoms presented were cough (21.3%), headache (15.7%), and sore throat (11.7%). Only 7.6% of the patients had a history of fever. Most patients were asymptomatic (51.65). Approximately 38.9% have an underlying co-morbid NCDs, with Hypertension (32.1%), Diabetes (9.9%), and Asthma (5.2%) being the three commonest. The odds of Moderate/severe (MoS) was significantly higher for those with unknown exposures to similar illness [aOR(95%CI) = 4.27(1.12-10.2)] compared with non-exposure to similar illness. An increased unit of NCD's count significantly increased the odds of COVID-19 MoS illness by 26%[cOR(95%CI) =1.26(1.09-1.84)] and 67% (adjusting for age) [aOR(95%CI)=1.67(1.13-2.49)].

CONCLUSION:

The presence of cardiovascular co-morbidities dictated the frequency of reported symptoms and severity of COVID-19 infection in this sample of Ghanaians. Physicians should be aware of the presence of co-morbid NCDs and prepare to manage effectively among COVID-19 patients.

FUNDING:

None declared.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Índice de Severidad de la Enfermedad / Enfermedades Cardiovasculares / Enfermedades no Transmisibles / SARS-CoV-2 / COVID-19 Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Adulto / Femenino / Humanos / Masculino / Middle aged País/Región como asunto: Africa Idioma: Inglés Revista: Ghana Med J Año: 2020 Tipo del documento: Artículo

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Índice de Severidad de la Enfermedad / Enfermedades Cardiovasculares / Enfermedades no Transmisibles / SARS-CoV-2 / COVID-19 Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Adulto / Femenino / Humanos / Masculino / Middle aged País/Región como asunto: Africa Idioma: Inglés Revista: Ghana Med J Año: 2020 Tipo del documento: Artículo