Combination of baloxavir and oseltamivir for treatment of severe influenza infection in hematopoietic cell transplant recipients: a novel treatment strategy for a high-risk population.

Angelidakis, Georgios; Khawaja, Fareed; Mulanovich, Victor E; Dailey-Garnes, Natalie; Ariza-Heredia, Ella; Chemaly, Roy F

Angelidakis, Georgios; Khawaja, Fareed; Mulanovich, Victor E; Dailey-Garnes, Natalie; Ariza-Heredia, Ella; Chemaly, Roy F.

Angelidakis G; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Khawaja F; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Mulanovich VE; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Dailey-Garnes N; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Ariza-Heredia E; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Chemaly RF; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: rfchemaly@mdanderson.org.

Microbes Infect ; 24(3): 104895, 2022.

Artículo en Inglés | MEDLINE | ID: covidwho-1487208

ABSTRACT

ABSTRACT

Baloxavir, a cap-dependent endonuclease inhibitor, was recently approved for treatment of severe influenza infections. Combining baloxavir with oseltamivir has been proposed to increase the response rate. We report 2 hematopoietic cell transplant recipients with severe influenza infections who were treated with this combination and discuss possible reasons for their different responses.

Asunto(s)

Trasplante de Células Madre Hematopoyéticas; Gripe Humana; Antivirales/uso terapéutico; Dibenzotiepinas; Trasplante de Células Madre Hematopoyéticas/efectos adversos; Humanos; Gripe Humana/tratamiento farmacológico; Gripe Humana/epidemiología; Morfolinas; Oseltamivir/uso terapéutico; Piridonas; Receptores de Trasplantes; Triazinas

Palabras clave

Baloxavir; Combination therapy; HCT; Influenza; Oseltamivir

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Trasplante de Células Madre Hematopoyéticas / Gripe Humana Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: Microbes Infect Asunto de la revista: Alergia e Inmunología / Microbiologia Año: 2022 Tipo del documento: Artículo País de afiliación: J.micinf.2021.104895

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