T follicular helper cells in the humoral immune response to SARS-CoV-2 infection and vaccination.
J Leukoc Biol
; 111(2): 355-365, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1499281
ABSTRACT
Vaccination remains the most effective mechanism to reduce the impact of COVID-19. Induction of neutralizing antibodies is a strong correlate of protection from infection and severe disease. An understanding of the cellular events that underpin the generation of effective neutralizing antibodies is therefore key to the development of efficacious vaccines that target emerging variants of concern. Analysis of the immune response to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and vaccination has identified circulating T follicular helper cells (cTFH ) as a robust correlate of the neutralizing antibody response. Here, we discuss the analysis of cTFH cells and their lymphoid counterparts in human humoral immune responses during COVID-19, and in response to vaccination with SARS-CoV-2 spike. We discuss the phenotypic heterogeneity of cTFH cells and the utility of cTFH subsets as informative biomarkers for development of humoral immunity. We posit that the analysis of the most effective cTFH will be critical to inducing durable immunity to new variants of SARS-CoV-2.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Inmunidad Humoral
/
Células T Auxiliares Foliculares
/
Vacunas contra la COVID-19
/
SARS-CoV-2
/
COVID-19
/
Inmunidad Celular
Tópicos:
Vacunas
/
Variantes
Límite:
Humanos
Idioma:
Inglés
Revista:
J Leukoc Biol
Año:
2022
Tipo del documento:
Artículo
País de afiliación:
JLB.5MR0821-464R
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