l-Arginine and COVID-19: An Update.

Adebayo, Ayobami; Varzideh, Fahimeh; Wilson, Scott; Gambardella, Jessica; Eacobacci, Michael; Jankauskas, Stanislovas S; Donkor, Kwame; Kansakar, Urna; Trimarco, Valentina; Mone, Pasquale; Lombardi, Angela; Santulli, Gaetano

Adebayo, Ayobami; Varzideh, Fahimeh; Wilson, Scott; Gambardella, Jessica; Eacobacci, Michael; Jankauskas, Stanislovas S; Donkor, Kwame; Kansakar, Urna; Trimarco, Valentina; Mone, Pasquale; Lombardi, Angela; Santulli, Gaetano.

Adebayo A; Department of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA.
Varzideh F; Department of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA.
Wilson S; Department of Molecular Pharmacology, Wilf Family Cardiovascular Research Institute, Einstein Institute for Neuroimmunology and Inflammation, Albert Einstein College of Medicine, New York, NY 10461, USA.
Gambardella J; Department of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA.
Eacobacci M; Department of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA.
Jankauskas SS; Department of Molecular Pharmacology, Wilf Family Cardiovascular Research Institute, Einstein Institute for Neuroimmunology and Inflammation, Albert Einstein College of Medicine, New York, NY 10461, USA.
Donkor K; Department of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA.
Kansakar U; Department of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA.
Trimarco V; Department of Molecular Pharmacology, Wilf Family Cardiovascular Research Institute, Einstein Institute for Neuroimmunology and Inflammation, Albert Einstein College of Medicine, New York, NY 10461, USA.
Mone P; Department of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA.
Lombardi A; Department of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA.
Santulli G; Department of Molecular Pharmacology, Wilf Family Cardiovascular Research Institute, Einstein Institute for Neuroimmunology and Inflammation, Albert Einstein College of Medicine, New York, NY 10461, USA.

Nutrients ; 13(11)2021 Nov 05.

Artículo en Inglés | MEDLINE | ID: covidwho-1502476

ABSTRACT

ABSTRACT

l-Arginine is involved in many different biological processes and recent reports indicate that it could also play a crucial role in the coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Herein, we present an updated systematic overview of the current evidence on the functional contribution of L-Arginine in COVID-19, describing its actions on endothelial cells and the immune system and discussing its potential as a therapeutic tool, emerged from recent clinical experimentations.

Asunto(s)

Arginina/metabolismo; COVID-19/metabolismo; Células Endoteliales/metabolismo; Sistema Inmunológico/metabolismo; SARS-CoV-2/patogenicidad; Animales; Arginina/uso terapéutico; COVID-19/inmunología; COVID-19/virología; Células Endoteliales/efectos de los fármacos; Células Endoteliales/inmunología; Células Endoteliales/virología; Interacciones Huésped-Patógeno; Humanos; Sistema Inmunológico/efectos de los fármacos; Sistema Inmunológico/inmunología; Sistema Inmunológico/virología; Óxido Nítrico/metabolismo; SARS-CoV-2/inmunología; Tratamiento Farmacológico de COVID-19

Palabras clave

COVID-19; ROS; SARS-CoV-2; T cells; antiviral therapies; arginine; coronavirus; cytokine storm; endothelium; immune response; immunity; inflammation; nitric oxide; nitrosylation; oxidative stress; viral infections

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Arginina / Células Endoteliales / SARS-CoV-2 / COVID-19 / Sistema Inmunológico Tipo de estudio: Estudio pronóstico / Revisiones / Revisión sistemática/Meta análisis Límite: Animales / Humanos Idioma: Inglés Año: 2021 Tipo del documento: Artículo País de afiliación: Nu13113951

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