Presentation, patterns and predictive value of baseline liver tests on outcomes in COVID-19 patients without chronic liver disease.
World J Gastroenterol
; 27(42): 7350-7361, 2021 Nov 14.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1526866
ABSTRACT
BACKGROUND:
Coronavirus disease 2019 (COVID-19) infection is known to cause abnormal hepatic enzymes. The long term consequences of such elevations are uncertain.AIM:
To assessed the prevalence and prognostic value of initial liver enzymes in a large cohort of COVID-19 patients.METHODS:
We reviewed electronic medical records of 10614 COVID-19 patients without known chronic liver disease who were admitted to our health system from March 1, 2020, to April 30, 2020. We analyzed baseline demographics and liver chemistries. The primary outcome was in-hospital mortality, and the secondary outcome was a composite of in-hospital mortality or need for mechanical ventilation.RESULTS:
Subjects with abnormal liver tests had increased risks of mortality and composite outcome when compared to patients with normal measurements on unadjusted analysis and after adjustment for demographic factors.CONCLUSION:
In our diverse patient population, liver enzyme abnormalities are associated with increased mortality and the need for mechanical ventilation in subjects without chronic liver disease. Cholestasis patients are at the greatest risk for poor outcomes.Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
COVID-19
/
Hepatopatías
Tipo de estudio:
Estudio de cohorte
/
Estudios diagnósticos
/
Estudio observacional
/
Estudio pronóstico
Tópicos:
Covid persistente
Límite:
Humanos
Idioma:
Inglés
Revista:
World J Gastroenterol
Asunto de la revista:
Gastroenterologia
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
Wjg.v27.i42.7350
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