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Heterogeneous immunogenicity of SARS-CoV-2 vaccines in cancer patients receiving radiotherapy.
Bowes, Cynthia L; Naranbhai, Vivek; St Denis, Kerri J; Lam, Evan C; Bertaux, Brittany; Keane, Florence K; Khandekar, Melin J; Balazs, Alejandro B; Iafrate, John A; Gainor, Justin F; Willers, Henning.
  • Bowes CL; Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA.
  • Naranbhai V; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • St Denis KJ; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
  • Lam EC; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
  • Bertaux B; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Keane FK; Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA.
  • Khandekar MJ; Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA.
  • Balazs AB; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
  • Iafrate JA; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
  • Gainor JF; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Willers H; Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA. Electronic address: hwillers@mgh.harvard.edu.
Radiother Oncol ; 166: 88-91, 2022 01.
Artículo en Inglés | MEDLINE | ID: covidwho-1537007
ABSTRACT
The immunogenicity of SARS-CoV-2 vaccines in cancer patients receiving radiotherapy is unknown. This prospective cohort study demonstrates that anti-SARS-CoV-2 spike antibody and neutralization titers are reduced in a subset of thoracic radiotherapy patients, possibly due to immunosuppressive conditions. Antibody testing may be useful to identify candidates for additional vaccine doses.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: COVID-19 / Neoplasias Tipo de estudio: Estudio de cohorte / Estudio observacional / Estudio pronóstico Tópicos: Vacunas Límite: Humanos Idioma: Inglés Revista: Radiother Oncol Año: 2022 Tipo del documento: Artículo País de afiliación: J.radonc.2021.11.012

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: COVID-19 / Neoplasias Tipo de estudio: Estudio de cohorte / Estudio observacional / Estudio pronóstico Tópicos: Vacunas Límite: Humanos Idioma: Inglés Revista: Radiother Oncol Año: 2022 Tipo del documento: Artículo País de afiliación: J.radonc.2021.11.012