Interindividual immunogenic variants: Susceptibility to coronavirus, respiratory syncytial virus and influenza virus.
Rev Med Virol
; 31(6): e2234, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1574124
ABSTRACT
The coronavirus disease (Covid-19) pandemic is the most serious event of the year 2020, causing considerable global morbidity and mortality. The goal of this review is to provide a comprehensive summary of reported associations between inter-individual immunogenic variants and disease susceptibility or symptoms caused by the coronavirus strains severe acute respiratory syndrome-associated coronavirus, severe acute respiratory syndrome-associated coronavirus-2, and two of the main respiratory viruses, respiratory syncytial virus and influenza virus. The results suggest that the genetic background of the host could affect the levels of proinflammatory and anti-inflammatory cytokines and might modulate the progression of Covid-19 in affected patients. Notably, genetic variations in innate immune components such as toll-like receptors and mannose-binding lectin 2 play critical roles in the ability of the immune system to recognize coronavirus and initiate an early immune response to clear the virus and prevent the development of severe symptoms. This review provides promising clues related to the potential benefits of using immunotherapy and immune modulation for respiratory infectious disease treatment in a personalized manner.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Infecciones por Virus Sincitial Respiratorio
/
Predisposición Genética a la Enfermedad
/
Síndrome Respiratorio Agudo Grave
/
Gripe Humana
/
Síndrome de Liberación de Citoquinas
/
COVID-19
Tópicos:
Variantes
Idioma:
Inglés
Revista:
Rev Med Virol
Asunto de la revista:
Virología
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
Rmv.2234
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