The state of complement in COVID-19.
Nat Rev Immunol
; 22(2): 77-84, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1585843
ABSTRACT
Hyperactivation of the complement and coagulation systems is recognized as part of the clinical syndrome of COVID-19. Here we review systemic complement activation and local complement activation in response to the causative virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and their currently known relationships to hyperinflammation and thrombosis. We also provide an update on early clinical findings and emerging clinical trial evidence that suggest potential therapeutic benefit of complement inhibition in severe COVID-19.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Proteínas del Sistema Complemento
/
COVID-19
Tipo de estudio:
Estudio pronóstico
/
Ensayo controlado aleatorizado
Límite:
Humanos
Idioma:
Inglés
Revista:
Nat Rev Immunol
Asunto de la revista:
Alergia e Inmunología
Año:
2022
Tipo del documento:
Artículo
País de afiliación:
S41577-021-00665-1
Similares
MEDLINE
...
LILACS
LIS