Epidemiology of acute respiratory viral infections in children in Vientiane, Lao People's Democratic Republic.
J Med Virol
; 93(8): 4748-4755, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1610624
ABSTRACT
Respiratory infections are one of the most frequent reasons for medical consultations in children. In low resource settings such as in Lao People's Democratic Republic, knowledge gaps and the dearth of laboratory capacity to support differential diagnosis may contribute to antibiotic overuse. We studied the etiology, temporal trends, and genetic diversity of viral respiratory infections in children to provide evidence for prevention and treatment guidelines. From September 2014 to October 2015, throat swabs and nasopharyngeal aspirates from 445 children under 10 years old with symptoms of acute respiratory infection were collected at the Children Hospital in Vientiane. Rapid antigen tests were performed for influenza A and B and respiratory syncytial virus. Real-time reverse-transcription polymerase chain reactions (RT-PCRs) were performed to detect 16 viruses. Influenza infections were detected with a higher sensitivity using PCR than with the rapid antigen test. By RT-PCR screening, at least one pathogen could be identified for 71.7% of cases. Human rhinoviruses were most frequently detected (29.9%), followed by influenza A and B viruses combined (15.9%). We identify and discuss the seasonality of some of the infections. Altogether these data provide a detailed characterization of respiratory pathogens in Lao children and we provide recommendations for vaccination and further studies.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Infecciones del Sistema Respiratorio
/
Virus
/
Virosis
/
Coinfección
Tipo de estudio:
Estudios diagnósticos
/
Estudio de etiologia
/
Estudio observacional
Tópicos:
Vacunas
Límite:
Niño
/
Child, preschool
/
Femenino
/
Humanos
/
Lactante
/
Masculino
/
Recién Nacido
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
J Med Virol
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
Jmv.27004
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