Oxidative Stress Status in COVID-19 Patients Hospitalized in Intensive Care Unit for Severe Pneumonia. A Pilot Study
Free Radical Biology and Medicine
; 177:S119-S120, 2021.
Artículo
en Inglés
| EMBASE | ID: covidwho-1623347
ABSTRACT
Background:
A key role of oxidative stress has been highlighted in the pathogenesis of COVID-19. However, little has been said about oxidative stress status (OSS) of COVID-19 patients hospitalized in intensive care unit (ICU). Material andMethods:
Biomarkers of the systemic OSS included antioxidants (9 assays), trace elements (3 assays), inflammation markers (4 assays) and oxidative damage to lipids (3 assays).Results:
Blood samples were drawn after 9 (7–11) and 41 (39–43) days of ICU stay, respectively in 3 and 6 patients. Vitamin C, thiol proteins, reduced glutathione, γ-tocopherol, β-carotene and PAOT® score were significantly decreased compared to laboratory reference values. Selenium concentration was at the limit of the lower reference value. By contrast, the copper/zinc ratio (as a source of oxidative stress) was higher than reference values in 55% of patients while copper was significantly correlated with lipid peroxides (r = 0.95, p < 0.001). Inflammatory biomarkers (C-reactive protein and myeloperoxidase) were significantly increased when compared to normals.Conclusions:
The systemic OSS was strongly altered in critically ill COVID-19 patients as evidenced by increased lipid peroxidation but also by deficits in some antioxidants (vitamin C, glutathione, thiol proteins) and trace elements (selenium).
antioxidant; ascorbic, acid; beta, carotene; biological, marker; C, reactive, protein; endogenous, compound; gamma, tocopherol; glutathione; lipid, peroxide; myeloperoxidase; selenium; thiol; trace, element; zinc; adult; blood, sampling; case, report; clinical, article; conference, abstract; coronavirus, disease, 2019; critically, ill, patient; female; human; intensive, care, unit; lipid, peroxidation; male; oxidative, stress; pilot, study; reference, value
Texto completo:
Disponible
Colección:
Bases de datos de organismos internacionales
Base de datos:
EMBASE
Idioma:
Inglés
Revista:
Free Radical Biology and Medicine
Año:
2021
Tipo del documento:
Artículo
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