Immunology of SARS-CoV-2 infection in children.
Nat Immunol
; 23(2): 177-185, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1671601
ABSTRACT
Children and adolescents exhibit a broad range of clinical outcomes from SARS-CoV-2 infection, with the majority having minimal to mild symptoms. Additionally, some succumb to a severe hyperinflammatory post-infectious complication called multisystem inflammatory syndrome in children (MIS-C), predominantly affecting previously healthy individuals. Studies characterizing the immunological differences associated with these clinical outcomes have identified pathways important for host immunity to SARS-CoV-2 and innate modulators of disease severity. In this Review, we delineate the immunological mechanisms underlying the spectrum of pediatric immune response to SARS-CoV-2 infection in comparison with that of adults.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Síndrome de Respuesta Inflamatoria Sistémica
/
SARS-CoV-2
/
COVID-19
/
Inmunidad Innata
Tipo de estudio:
Estudios diagnósticos
/
Estudio pronóstico
Tópicos:
Covid persistente
Límite:
Adolescente
/
Niño
/
Humanos
Idioma:
Inglés
Revista:
Nat Immunol
Asunto de la revista:
Alergia e Inmunología
Año:
2022
Tipo del documento:
Artículo
País de afiliación:
S41590-021-01123-9
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