Diverse Roles of TRPV4 in Macrophages: A Need for Unbiased Profiling.
Front Immunol
; 12: 828115, 2021.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1680008
ABSTRACT
Transient receptor potential vanilloid 4 (TRPV4) is a non-selective mechanosensitive ion channel expressed by various macrophage populations. Recent reports have characterized the role of TRPV4 in shaping the activity and phenotype of macrophages to influence the innate immune response to pathogen exposure and inflammation. TRPV4 has been studied extensively in the context of inflammation and inflammatory pain. Although TRPV4 activity has been generally described as pro-inflammatory, emerging evidence suggests a more complex role where this channel may also contribute to anti-inflammatory activities. However, detailed understanding of how TRPV4 may influence the initiation, maintenance, and resolution of inflammatory disease remains limited. This review highlights recent insights into the cellular processes through which TRPV4 contributes to pathological conditions and immune processes, with a focus on macrophage biology. The potential use of high-throughput and omics methods as an unbiased approach for studying the functional outcomes of TRPV4 activation is also discussed.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Regulación de la Expresión Génica
/
Canales Catiónicos TRPV
/
Macrófagos
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Front Immunol
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
Fimmu.2021.828115
Similares
MEDLINE
...
LILACS
LIS