Genetic ancestry effects on the response to viral infection are pervasive but cell type specific.
Science
; 374(6571): 1127-1133, 2021 Nov 26.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1723460
ABSTRACT
Humans differ in their susceptibility to infectious disease, partly owing to variation in the immune response after infection. We used single-cell RNA sequencing to quantify variation in the response to influenza infection in peripheral blood mononuclear cells from European- and African-ancestry males. Genetic ancestry effects are common but highly cell type specific. Higher levels of European ancestry are associated with increased type I interferon pathway activity in early infection, which predicts reduced viral titers at later time points. Substantial population-associated variation is explained by cis-expression quantitative trait loci that are differentiated by genetic ancestry. Furthermore, genetic ancestryassociated genes are enriched among genes correlated with COVID-19 disease severity, suggesting that the early immune response contributes to ancestry-associated differences for multiple viral infection outcomes.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Negro o Afroamericano
/
Leucocitos Mononucleares
/
Población Blanca
/
Gripe Humana
/
Subtipo H1N1 del Virus de la Influenza A
/
COVID-19
Tipo de estudio:
Estudio experimental
/
Estudio pronóstico
Límite:
Adulto
/
Anciano
/
Humanos
/
Masculino
/
Middle aged
/
Young_adult
Idioma:
Inglés
Revista:
Science
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
Science.abg0928
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