Early changes in laboratory tests predict liver function damage in patients with moderate coronavirus disease 2019: a retrospective multicenter study.
BMC Gastroenterol
; 22(1): 113, 2022 Mar 09.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1736342
ABSTRACT
BACKGROUND:
Most patients with coronavirus disease 2019 demonstrate liver function damage. In this study, the laboratory test data of patients with moderate coronavirus disease 2019 were used to establish and evaluate an early prediction model to assess the risk of liver function damage.METHODS:
Clinical data and the first laboratory examination results of 101 patients with moderate coronavirus disease 2019 were collected from four hospitals' electronic medical record systems in Jilin Province, China. Data were randomly divided into training and validation sets. A logistic regression analysis was used to determine the independent factors related to liver function damage in patients in the training set to establish a prediction model. Model discrimination, calibration, and clinical usefulness were evaluated in the training and validation sets.RESULTS:
The logistic regression analysis showed that plateletcrit, retinol-binding protein, and carbon dioxide combining power could predict liver function damage (P < 0.05 for all). The receiver operating characteristic curve showed high model discrimination (training set area under the curve 0.899, validation set area under the curve 0.800; P < 0.05). The calibration curve showed a good fit (training set P = 0.59, validation set P = 0.19; P > 0.05). A decision curve analysis confirmed the clinical usefulness of this model.CONCLUSIONS:
In this study, the combined model assesses liver function damage in patients with moderate coronavirus disease 2019 performed well. Thus, it may be helpful as a reference for clinical differentiation of liver function damage. Trial registration retrospectively registered.Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
COVID-19
Tipo de estudio:
Estudio experimental
/
Estudio observacional
/
Estudio pronóstico
/
Ensayo controlado aleatorizado
Límite:
Humanos
Idioma:
Inglés
Revista:
BMC Gastroenterol
Asunto de la revista:
Gastroenterologia
Año:
2022
Tipo del documento:
Artículo
País de afiliación:
S12876-022-02188-Y
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