Sex-related differences in patients with coronavirus disease 2019: results of the Cardio-COVID-Italy multicentre study.
J Cardiovasc Med (Hagerstown)
; 23(4): 254-263, 2022 04 01.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1742158
ABSTRACT
INTRODUCTION:
The role of sex compared to comorbidities and other prognostic variables in patients with coronavirus disease (COVID-19) is unclear.METHODS:
This is a retrospective observational study on patients with COVID-19 infection, referred to 13 cardiology units. The primary objective was to assess the difference in risk of death between the sexes. The secondary objective was to explore sex-based heterogeneity in the association between demographic, clinical and laboratory variables, and patients' risk of death.RESULTS:
Seven hundred and one patients were included 214 (30.5%) women and 487 (69.5%) men. During a median follow-up of 15âdays, deaths occurred in 39 (18.2%) women and 126 (25.9%) men. In a multivariable Cox regression model, men had a nonsignificantly higher risk of death vs. women (P = 0.07).The risk of death was more than double in men with a low lymphocytes count as compared with men with a high lymphocytes count [overall survival hazard ratio (OS-HR) 2.56, 95% confidence interval (CI) 1.72-3.81]. In contrast, lymphocytes count was not related to death in women (Pâ=â0.03).Platelets count was associated with better outcome in men (OS-HR for increase of 50â×â103 units 0.88 95% CI 0.78-1.00) but not in women. The strength of association between higher PaO2/FiO2 ratio and lower risk of death was larger in women (OS-HR for increase of 50âmmHg/% 0.72, 95% CI 0.59-0.89) vs. men (OS-HR 0.88, 95% CI 0.80-0.98; Pâ=â0.05).CONCLUSIONS:
Patients' sex is a relevant variable that should be taken into account when evaluating risk of death from COVID-19. There is a sex-based heterogeneity in the association between baseline variables and patients' risk of death.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
COVID-19
Tipo de estudio:
Estudio de cohorte
/
Estudio experimental
/
Estudio observacional
/
Estudio pronóstico
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
J Cardiovasc Med (Hagerstown)
Asunto de la revista:
Angiología
/
Cardiología
Año:
2022
Tipo del documento:
Artículo
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