Spherical nucleic acids as an infectious disease vaccine platform.
Proc Natl Acad Sci U S A
; 119(14): e2119093119, 2022 04 05.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1751830
ABSTRACT
SignificanceUsing SARS-CoV-2 as a relevant case study for infectious disease, we investigate the structure-function relationships that dictate antiviral spherical nucleic acid (SNA) vaccine efficacy. We show that the SNA architecture can be rapidly employed to target COVID-19 through incorporation of the receptor-binding domain, and that the resulting vaccine potently activates human cells in vitro and mice in vivo. Furthermore, when challenged with a lethal viral infection, only mice treated with the SNA vaccine survived. Taken together, this work underscores the importance of rational vaccine design for infectious disease to yield vaccines that elicit more potent immune responses to effectively fight disease.
Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Ácidos Nucleicos
/
Control de Enfermedades Transmisibles
/
Vacunas de ADN
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Tópicos:
Vacunas
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Proc Natl Acad Sci U S A
Año:
2022
Tipo del documento:
Artículo
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